Kuraridine

Modify Date: 2024-01-02 16:31:13

Kuraridine structure	Common Name	Kuraridine
	CAS Number	34981-25-4	Molecular Weight	438.51300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₀O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Kuraridine

Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) and has an IC50 of 0.64 μM[1].

Name	Kuraridine
Synonym	More Synonyms

Description	Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) and has an IC50 of 0.64 μM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Others
Target	PDE5:0.64 μM (IC50)
In Vitro	Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively[1]. Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal IGABA induced by a saturating GABA concentration (1 mM)[2]. Kuraridine induces a concentration–response curves for IGABA enhancement (EC50=4.0±2.4 μM) in Xenopus oocytes expressing GABAA receptors composed of α1, β2, and γ2S subunits[2].
References	[1]. Hye Joo Shin, et al. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. [2]. Xinzhou Yang, et al. HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root). Mol Divers. 2011 May;15(2):361-72.

Molecular Formula	C₂₆H₃₀O₆
Molecular Weight	438.51300
Exact Mass	438.20400
PSA	107.22000
LogP	5.50480

6'-methoxy-2,4,2',4'-tetrahydroxy-3'-lavandulylchalcone

kuraridin

kuraridine

(E)-1-[2,4-Dihydroxy-3-(2-isopropenyl-5-methyl-hex-4-enyl)-6-methoxy-phenyl]-3-(2,4-dihydroxy-phenyl)-propenone

BioBioPha
China
Product Name: Kuraridin
Price: ￥3900.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Kuraridine
Price: ￥4418.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Kuraridine
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Kuraridine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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