UNII:M73AI9718D
Modify Date: 2024-01-06 07:49:50
UNII:M73AI9718D structure
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Common Name | UNII:M73AI9718D | ||
|---|---|---|---|---|
| CAS Number | 333-31-3 | Molecular Weight | 240.138 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H18BrNO2 | Melting Point | 147-149ºC(lit.) | |
| MSDS | N/A | Flash Point | N/A | |
Use of UNII:M73AI9718DMethacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4]. |
| Name | methacholine bromide |
|---|---|
| Synonym | More Synonyms |
| Description | Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4]. |
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| Related Catalog | |
| In Vivo | Methacholine bromide (0.5 µg/kg plus 5 µg/kg/min for 30 min) induces bronchoconstriction in dogs[4]. Methacholine bromide (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 µg/kg; i.v.) in a a dose-dependent manner in mouse[5]. Animal Model: 9-week female BALB/c mice[6] Dosage: 0.03, 0.1, 0.3, 1 mg/kg Administration: I.v Result: Induced severe bronchoconstriction. |
| References |
[3]. Cockcroft DW. Methacholine challenge methods. Chest. 2008;134(4):678-680. |
| Melting Point | 147-149ºC(lit.) |
|---|---|
| Molecular Formula | C8H18BrNO2 |
| Molecular Weight | 240.138 |
| Exact Mass | 239.052078 |
| PSA | 26.30000 |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| HS Code | 2923900090 |
|
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UNII:M73AI9718D CAS#:333-31-3 |
| Literature: Journal of Pharmacology and Experimental Therapeutics, , vol. 51, p. 258 Chem. Zentralbl., , vol. 106, # I p. 436 |
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UNII:M73AI9718D CAS#:333-31-3 |
| Literature: US2192204 , ; |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
| HS Code | 2923900090 |
|---|---|
| Summary | 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
| 2-Acetoxy-N,N,N-trimethyl-1-propanaminium bromide |
| METHYLCHOLINE BROMIDE |
| UNII:M73AI9718D |
| metacholine |
| ACETYL-B-METHYLCHOLINE BROMIDE |
| Acetyl-β-methylcholine bromide |
| Acetyl-beta-methylcholine bromide |
| O-Acetyl-β-methylcholine Bromide |
| MECHOLYL BROMIDE |
| ACETYL SS-METHYLCHOLINE BROMIDE |
| MFCD00011816 |
| 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide (1:1) |
| Methacholine |
| 2-acetoxy-n,n,n-trimethylpropan-1-aminium bromide |
| EINECS 206-372-2 |
| 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: UNII:M73AI9718D
- Price: ￥338.0/5g ￥3608.0/100g ￥1318.0/25g
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: methacholine bromide
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
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Price: ￥7464.6/500g
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