Periplocymarin

Modify Date: 2024-01-09 18:30:09

Periplocymarin structure	Common Name	Periplocymarin
	CAS Number	32476-67-8	Molecular Weight	534.68100
	Density	1.27±0.1 g/cm3 (20 ºC 760 Torr)	Boiling Point	690.9±55.0℃ at 760 mmHg
	Molecular Formula	C₃₀H₄₆O₈	Melting Point	209-211 ºC
	MSDS	N/A	Flash Point	N/A

Use of Periplocymarin

Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound[1][2].

Name	4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Synonym	More Synonyms

Description	Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Periplocymarin inhibits proliferation of PC3, U937, HCT-8, Bel-7402, BGC823, A549, and A2780 cell lines in vitro with IC50 values of 0.02-0.29 µM[2].
References	[1]. Martey ON, et al. Periplocymarin is a potential natural compound for drug development: highly permeable with absence of P-glycoprotein efflux and cytochrome P450 inhibitions. Biopharm Drug Dispos. 2014 May;35(4):195-206. [2]. Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfidebond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy. Drug Deliv. 2017 Nov;24(1):1170-1178.

Density	1.27±0.1 g/cm3 (20 ºC 760 Torr)
Boiling Point	690.9±55.0℃ at 760 mmHg
Melting Point	209-211 ºC
Molecular Formula	C₃₀H₄₆O₈
Molecular Weight	534.68100
Exact Mass	534.31900
PSA	114.68000
LogP	3.25430
Water Solubility	Very slightly soluble (0.43 g/L) (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FH4920610

CHEMICAL NAME :: 5-beta-Card-20(22)-enolide, 3-beta-((2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyran osyl)oxy)- 5,14-dihydroxy-

CAS REGISTRY NUMBER :: 32476-67-8

LAST UPDATED :: 199304

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C30-H46-O8

MOLECULAR WEIGHT :: 534.76

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 IQ MQ F- DT5OV EHJ& OO- FT6OTJ B1 CQ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 155 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 74,223,1942

periplocymarin