Deoxyelephantopin

Modify Date: 2024-01-11 06:38:54

Deoxyelephantopin structure	Common Name	Deoxyelephantopin
	CAS Number	29307-03-7	Molecular Weight	344.358
	Density	1.3±0.1 g/cm3	Boiling Point	584.3±50.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₀O₆	Melting Point	150-153℃
	MSDS	Chinese	Flash Point	258.1±30.2 °C

Use of Deoxyelephantopin

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling[1].

Name	Elephantopus carolinianus compd. B
Synonym	More Synonyms

Description	Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling[1].
Related Catalog	Research Areas >> Cancer
Target	NF-κB
In Vitro	Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively[1]. Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells[1].
References	[1]. Farha Arakkaveettil Kabeer, et al. Molecular Mechanisms of Anticancer Activity of Deoxyelephantopin in Cancer Cells. Integr Med Res. 2017 Jun;6(2):190-206.

Density	1.3±0.1 g/cm3
Boiling Point	584.3±50.0 °C at 760 mmHg
Melting Point	150-153℃
Molecular Formula	C₁₉H₂₀O₆
Molecular Weight	344.358
Flash Point	258.1±30.2 °C
Exact Mass	344.125977
PSA	78.90000
LogP	1.51
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.556

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LY4250000

CAS REGISTRY NUMBER :: 29307-03-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H20-O6

MOLECULAR WEIGHT :: 344.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 2143 umol/L

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1235,1978

Hazard Codes	Xi

Deoxyelephantopin

(3S,4R,8R,9Z,12R)-10-Methyl-5-methylene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.0]pentadeca-1(15),9-dien-3-yl methacrylate

2-Propenoic acid, 2-methyl-, (3aR,4S,9R,11Z,12aR)-2,3,3a,4,5,9,10,12a-octahydro-11-methyl-3-methylene-2,7-dioxo-7H-9,6-methenofuro[2,3-f]oxacycloundecin-4-yl ester

Isodeoxyelephantopin