5-Hydroxy-3',4',7-trimethoxyflavone

Modify Date: 2024-01-02 18:09:56

5-Hydroxy-3',4',7-trimethoxyflavone Structure
5-Hydroxy-3',4',7-trimethoxyflavone structure
Common Name 5-Hydroxy-3',4',7-trimethoxyflavone
CAS Number 29080-58-8 Molecular Weight 328.316
Density 1.3±0.1 g/cm3 Boiling Point 536.3±50.0 °C at 760 mmHg
Molecular Formula C18H16O6 Melting Point N/A
MSDS N/A Flash Point 197.0±23.6 °C

 Use of 5-Hydroxy-3',4',7-trimethoxyflavone


7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid from the herb Lippia nodiflora L. (Verbenaceae) which has been documented to exhibit anti-inflammatory, antipyretic, antitussive, antidiabetic, anticancer, and antimelanogenesis properties. 7,3',4'-Tri-O-methylluteolin obviously reduces the prodn of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β in a concentration-dependent manner. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level[1].

 Names

Name 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one
Synonym More Synonyms

 5-Hydroxy-3',4',7-trimethoxyflavone Biological Activity

Description 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid from the herb Lippia nodiflora L. (Verbenaceae) which has been documented to exhibit anti-inflammatory, antipyretic, antitussive, antidiabetic, anticancer, and antimelanogenesis properties. 7,3',4'-Tri-O-methylluteolin obviously reduces the prodn of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β in a concentration-dependent manner. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level[1].
Related Catalog
Target

TNF-α

IL-6

IL-1β

References

[1]. Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25(9), 1754–1767.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 536.3±50.0 °C at 760 mmHg
Molecular Formula C18H16O6
Molecular Weight 328.316
Flash Point 197.0±23.6 °C
Exact Mass 328.094696
PSA 78.13000
LogP 3.22
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.606

 Safety Information

Hazard Codes Xi
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxy-
2-(3,4-Dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one
5-Hydroxy-3',4',7-trimethoxyflavone
luteolin-3'-4',7-trimethyl ether
5-hydroxy-7,2',6'-trimethoxyflavone
5-hydroxy-7,3',4'-trimethoxy-flavone
Luteolin-7,3',4'-trimethylether
5-hydroxy-7,3',4'-trimethoxyflavone