L(-)-Glutathione

Modify Date: 2024-01-02 18:50:33

L(-)-Glutathione Structure
L(-)-Glutathione structure
 Common Name L(-)-Glutathione
CAS Number 27025-41-8 Molecular Weight 612.631
Density 1.7±0.1 g/cm3 Boiling Point 976.3±75.0 °C at 760 mmHg
Molecular Formula C20H32N6O12S2 Melting Point 178 °C (dec.)(lit.)
MSDS USA Flash Point 544.3±37.1 °C

 Use of L(-)-Glutathione


Glutathione oxidized is produced by the oxidation of glutathione which is a major intracellular antioxidant and detoxifying agent.

 Names

Name glutathione disulfide
Synonym More Synonyms

 L(-)-Glutathione Biological Activity

Description Glutathione oxidized is produced by the oxidation of glutathione which is a major intracellular antioxidant and detoxifying agent.
Related Catalog
Target

Human Endogenous Metabolite
References

[1]. Nur E, et al. Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes. Biochim Biophys Acta. 2011 Nov;1812(11):1412-7.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 976.3±75.0 °C at 760 mmHg
Melting Point 178 °C (dec.)(lit.)
Molecular Formula C20H32N6O12S2
Molecular Weight 612.631
Flash Point 544.3±37.1 °C
Exact Mass 612.151978
PSA 368.24000
LogP 1.91
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.677
Storage condition 2~8°C
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MC0556500
CHEMICAL NAME :
Glycine, L-gamma-glutamyl-L-cysteinyl-, (2,2')-disulfide
CAS REGISTRY NUMBER :
27025-41-8
LAST UPDATED :
199212
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H32-N6-O12-S2
MOLECULAR WEIGHT :
612.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS MC0556500

 Synthetic Route

 Articles115

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Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice.

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Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome.

PLoS ONE 9(8) , e104637, (2014)

SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this mode...

 Synonyms

Glutathione disulfide
Glutathione (oxidized form)
GSSG,Glutathiol
Glutathiol,GSSG
L-Glutathione oxidized
(2S,5Z,2'S,5'E)-5,5'-[Disulfanediylbis({(2R,3Z)-3-[(carboxymethyl)imino]-3-hydroxy-1,2-propanediyl}nitrilo)]bis(2-amino-5-hydroxypentanoic acid) (non-preferred name)
oxigluthione
glutathonedisulfide
glutathione-ssg
Oxiglutatione
GSH disulfide
GSSC
MFCD00063106
N,N'-(Dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-L-glutamine
GSSG
N-(N-g-Glutamyl-cysteinyl)glycine-(2,2)-disulfide
L(-)-Glutathione
Glutathiol
Oxyglutatione
(2S,2'S)-5,5'-[Disulfanediylbis({(2R)-3-[(carboxymethyl)amino]-3-oxo-1,2-propanediyl}imino)]bis(2-amino-5-oxopentanoic acid)
glutathione oxidized
EINECS 248-170-7
glutathione oxidized form
Oxidized glutathione
GSSG oxidized form
(2S,2'S)-5,5'-[Disulfanediylbis({(2R)-3-[(carboxymethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-amino-5-oxopentanoic acid) (non-preferred name)
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