Bruceine A

Modify Date: 2024-01-08 18:25:55

Bruceine A structure	Common Name	Bruceine A
	CAS Number	25514-31-2	Molecular Weight	522.542
	Density	1.4±0.1 g/cm3	Boiling Point	712.6±60.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₃₄O₁₁	Melting Point	N/A
	MSDS	N/A	Flash Point	237.1±26.4 °C

Use of Bruceine A

Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.IC50 value:Target: Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection.

Name	brucein a
Synonym	More Synonyms

Description	Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.IC50 value:Target: Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection Natural Products >> Others
References	[1]. Nakao R, et al. Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis. J Vet Med Sci. 2009 Jan;71(1):33-41.

Density	1.4±0.1 g/cm3
Boiling Point	712.6±60.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₄O₁₁
Molecular Weight	522.542
Flash Point	237.1±26.4 °C
Exact Mass	522.210083
PSA	165.89000
LogP	1.80
Vapour Pressure	0.0±5.2 mmHg at 25°C
Index of Refraction	1.596
Storage condition	-20°C