Glisoxepid

Modify Date: 2024-01-10 01:07:18

Glisoxepid structure	Common Name	Glisoxepid
	CAS Number	25046-79-1	Molecular Weight	449.52400
	Density	1.37g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₇N₅O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Glisoxepid

Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect[1][2][3].

Name	N-[2-[4-(azepan-1-ylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Synonym	More Synonyms

Description	Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	K(ATP) channel[1]
In Vitro	Glisoxepide inhibits the uptake of bile acids into isolated rat hepatocytes[3]. Glisoxepide noncompetitively inhibits the cholate uptake with a Ki of 200 μM[3].
References	[1]. Sato T, et al. Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J Pharmacol Exp Ther. 2006 Jan;316(1):182-8. Epub 2005 Sep 20. [2]. Selvaag E. Photohemolytic potency of oral antidiabetic drugs in vitro: effects of antioxidants and a nitrogen atmosphere. Photodermatol Photoimmunol Photomed. 1996 Aug;12(4):166-70. [3]. Fückel D, et al. Interaction of sulfonylureas with the transport of bile acids into hepatocytes. Eur J Pharmacol. 1992 Mar 31;213(3):393-404.

Density	1.37g/cm3
Molecular Formula	C₂₀H₂₇N₅O₅S
Molecular Weight	449.52400
Exact Mass	449.17300
PSA	142.02000
LogP	3.92580
Index of Refraction	1.617

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY2350000

CHEMICAL NAME :: 3-Isoxazolecarboxamide, N-(2-(4-(((((hexahydro-1H-azepin-1-yl)amino)carbonyl) amino)sulfonyl) phenyl)ethyl)-5-methyl-

CAS REGISTRY NUMBER :: 25046-79-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C20-H27-N5-O5-S

MOLECULAR WEIGHT :: 449.58

WISWESSER LINE NOTATION :: T7NTJ AMVMSWR D2MV- ET5NOJ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,409,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 196 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,409,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,409,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 283 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,409,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,409,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,409,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,409,1974

5-Methylisoxazo...

CAS#:39499-34-8

Glisoxepid

CAS#:25046-79-1

Literature: Arzneimittel-Forschung, , vol. 24, # 0 p. 363 - 374

4-(2-aminoethyl...

CAS#:6325-22-0

Glisoxepid

CAS#:25046-79-1

Literature: Arzneimittel-Forschung, , vol. 24, # 0 p. 363 - 374

4-[2-(5-Methyl-...

CAS#:24477-36-9

Glisoxepid

CAS#:25046-79-1

Literature: Arzneimittel-Forschung, , vol. 24, # 0 p. 363 - 374

1,1-Hexamethyle...

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{4-[2-(5-methyl...

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Glisoxepid

CAS#:25046-79-1

Literature: Arzneimittel-Forschung, , vol. 24, # 0 p. 363 - 374

Precursor 5
CAS#:39499-34-8 5-Methylisoxazo... CAS#:6325-22-0 4-(2-aminoethyl... CAS#:24477-36-9 4-[2-(5-Methyl-... CAS#:5906-35-4 1,1-Hexamethyle...
CAS#:24489-02-9 {4-[2-(5-methyl...
DownStream 0

Glisoxepida [INN-Spanish]

Glisepin

Glisoxepida

Glisoxepid

Glisoxepide

5-methyl-isoxazole-3-carboxylic acid 4-(azepan-1-ylcarbamoyl-sulfamoyl)-phenethylamide

Glisoxepida [Spanish]

N-{2-[4-({[(azepan-1-ylamino)carbonyl]amino}sulfonyl)phenyl]ethyl}-5-methylisoxazole-3-carboxamide

Glisoxepidum

Glisoxepidum [INN-Latin]

N-{2-[4-({[(azepan-1-yIamino)carbonyI]amino}suIfonyl)phenyI]ethyI}-5-methylisoxazole-3-carboxamide

Glisoxepide (INN)

Pro-Diaban

DC Chemicals Limited
China
Product Name: Glisoxepide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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