PI3K-IN-34
Modify Date: 2023-01-17 20:42:18
PI3K-IN-34 structure
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Common Name | PI3K-IN-34 | ||
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| CAS Number | 2458163-94-3 | Molecular Weight | 430.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H22N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PI3K-IN-34PI3K-IN-34 (Compound 6g) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research[1]. |
| Name | PI3K-IN-34 |
|---|
| Description | PI3K-IN-34 (Compound 6g) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research[1]. |
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| Related Catalog | |
| Target |
PI3Kα:8.43 μM (IC50) PI3Kβ:15.84 μM (IC50) PI3Kδ:30.62 μM (IC50) |
| In Vitro | PI3K-IN-34 (Compound 6g) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro[1]. PI3K-IN-34 (Compound 6g) induces cell cycle arrest toward the G2-M phase (45.75%) and leads to DNA synthesis and apoptosis[1]. PI3K-IN-34 (Compound 6g) (10 μM, 48 hours) results in apoptotic with 22.83% of cells in the early and latest age[1]. Cell Cytotoxicity Assay[1] Cell Line: Leukemia SR cell lines. Concentration: 10 μM Incubation Time: 48 hours Result: Antiproliferative activity with values of 4.37 μM. |
| References |
| Molecular Formula | C23H22N6O3 |
|---|---|
| Molecular Weight | 430.46 |