HDAC-IN-38

Modify Date: 2023-01-26 11:20:12

HDAC-IN-38 structure	Common Name	HDAC-IN-38
	CAS Number	2408123-36-2	Molecular Weight	461.98
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₈ClN₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDAC-IN-38

HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5)[1].

Name	HDAC-IN-38

Description	HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5)[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC8:0.533 μM (IC50) HDAC6:1.27 μM (IC50) HDAC3:2.86 μM (IC50) HDAC1:3.82 μM (IC50) HDAC5:6.27 μM (IC50) HDAC2:6.62 μM (IC50)
References	[1]. Kaur N, et al. Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. Eur J Med Chem. 2020 Feb 1;187:111915.

Molecular Formula	C₂₇H₂₈ClN₃O₂
Molecular Weight	461.98

HDAC-IN-38

Use of HDAC-IN-38

Names

HDAC-IN-38 Biological Activity

Chemical & Physical Properties