Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate

Modify Date: 2024-01-09 18:07:20

Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate structure	Common Name	Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate
	CAS Number	2244-11-3	Molecular Weight	160.085
	Density	1.681g/cm3	Boiling Point	374.1ºC at 760 mmHg
	Molecular Formula	C₄H₄N₂O₅	Melting Point	255 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	180ºC
	Symbol	GHS07	Signal Word	Warning

Use of Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate

Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2].

Name	Alloxan monohydrate
Synonym	More Synonyms

Description	Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
In Vitro	Alloxan hydrate inhibits the peptidase activities of the purified 26S and 20S proteasomes[1].
References	[1]. Zhou W, et al. Diabetogenic agent alloxan is a proteasome inhibitor. Biochem Biophys Res Commun. 2017;488(2):400-406. [2]. Munday R, et al. The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. J Endocrinol. 1993;139(1):153-163.

Density	1.681g/cm3
Boiling Point	374.1ºC at 760 mmHg
Melting Point	255 °C (dec.)(lit.)
Molecular Formula	C₄H₄N₂O₅
Molecular Weight	160.085
Flash Point	180ºC
Exact Mass	160.012024
PSA	115.73000
Vapour Pressure	8.59E-07mmHg at 25°C
Storage condition	2-8°C
Water Solubility	H2O: may be hazy yellow

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW0492000

CHEMICAL NAME :: 2,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate

CAS REGISTRY NUMBER :: 2244-11-3

LAST UPDATED :: 199603

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H2-N2-O4.H2-O

MOLECULAR WEIGHT :: 160.10

WISWESSER LINE NOTATION :: T6MVMVVVJ &QH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Endocrine - diabetes mellitus Endocrine - hyperglycemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 65400 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 60 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 1 pph

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,325,1985

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UW0492000
HS Code	29335995

Precursor 0
DownStream 2
CAS#:76002-68-1 6,7-dichloroqui... CAS#:79828-16-3 Benzo[g]pteridi...

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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MFCD00149399

2,4,5,6-Tetraoxypyrimidine

2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate

alloxan hydrate

2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate (1:1)

ALLOXAN MONOHYDRATE

alloxane monohydrate

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2,4,5,6(1H,3H)-Pyrimidinetetrone, hydrate (1:1)

Alloxan-monohydrat

5,6-Dioxyuracil

alloxane hydrate

Alloxan,monohydrate

Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate

EINECS 251-501-8

Pyrimidine-2,4,5,6(1H,3H)-tetrone hydrate (1:1)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate
Price: ￥578.0/25g ￥158.0/5g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Alloxan Monohydrate
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Alloxan monohydrate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Alloxan monohydrate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Use of Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate

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