R18 TFA

Modify Date: 2024-01-09 23:51:16

R18 TFA Structure
R18 TFA structure
Common Name R18 TFA
CAS Number 211364-78-2 Molecular Weight 2309.686
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C101H157N27O29S3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of R18 TFA


R18 is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].

 Names

Name L-Prolyl-L-histidyl-L-cysteinyl-L-valyl-L-prolyl-L-arginyl-L-α-aspartyl-L-leucyl-L-seryl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-leucyl-L-α-glutamyl-L-alanyl-L-asparaginyl-L-methionyl-L-cysteinyl-L-leucyl-L-proline
Synonym More Synonyms

 R18 TFA Biological Activity

Description R18 is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].
Related Catalog
References

[1]. B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38(38):12499-504.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C101H157N27O29S3
Molecular Weight 2309.686
Exact Mass 2308.080322
LogP 2.90
Index of Refraction 1.680

 Synonyms

L-Proline, L-prolyl-L-histidyl-L-cysteinyl-L-valyl-L-prolyl-L-arginyl-L-α-aspartyl-L-leucyl-L-seryl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-leucyl-L-α-glutamyl-L-alanyl-L-asparaginyl-L-methio
 nyl-L-cysteinyl-L-leucyl-
L-Prolyl-L-histidyl-L-cysteinyl-L-valyl-L-prolyl-L-arginyl-L-α-aspartyl-L-leucyl-L-seryl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-leucyl-L-α-glutamyl-L-alanyl-L-asparaginyl-L-methionyl-L-cyste
 inyl-L-leucyl-L-proline
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: R18 TFA
  • Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


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