H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2 trifluoroacetate salt (Disulfide bond)

Modify Date: 2023-02-18 10:09:52

H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2 trifluoroacetate salt (Disulfide bond) structure	Common Name	H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2 trifluoroacetate salt (Disulfide bond)
	CAS Number	209006-18-8	Molecular Weight	1175.85
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₉H₇₁ClN₁₂O₈S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2 trifluoroacetate salt (Disulfide bond)

PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM[1].

Name	H-P-CHLORO-PHE-D-CYS-β-(3-PYRIDYL)-ALA-D-TRP-LYS-TBU-GLY-CYS-2-NAL-NH2
Synonym	More Synonyms

Description	PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Urotensin Receptor
Target	hsst2:12 nM (Ki) hsst3:100 nM (Ki) hsst5:520 nM (Ki) hsst4:895 nM (Ki) hsst1:>1000 nM (Ki) hsst2:1.8 nM (IC50, rat antagonist bioassay versus somatostatin) rat urotensin II receptor:293 nM (Ki) human urotensin II receptor:562 nM (Ki)
In Vitro	PRL 2915 (0.3-30 nM; 30 min) 剂量依赖性地阻断人尿紧张素 II (human urotensin II) 诱导的大鼠主动脉环的强张性收缩[2]。
References	[1]. Hocart SJ, et al. Highly potent cyclic disulfide antagonists of somatostatin. J Med Chem. 1999 Jun 3;42(11):1863-71. [2]. Rossowski WJ, et al. Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists. Eur J Pharmacol. 2002 Mar 8;438(3):159-70.

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