CP-346086
Modify Date: 2024-01-14 12:30:52
CP-346086 structure
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Common Name | CP-346086 | ||
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| CAS Number | 186390-48-7 | Molecular Weight | 477.48100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H22F3N5O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of CP-346086CP-346086 is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 can lower plasma cholesterol and triglycerides in vivo[1]. |
| Name | CP-346086 dihydrate |
|---|---|
| Synonym | More Synonyms |
| Description | CP-346086 is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 can lower plasma cholesterol and triglycerides in vivo[1]. |
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| Related Catalog | |
| Target |
IC50: 2.0 nM (MTP)[1] |
| In Vitro | CP-346086 (0.1-1000 nM) dose-dependently inhibits human MTP-mediated triglyceride transfer between vesicles with an IC50 of 2.0 nM[1]. CP-346086 (24 h) inhibits apolipoprotein B (apoB) and triglyceride secretion (IC50=2.6 nM) from Hep-G2 cells without affecting apoA-I secretion or lipid synthesis[1]. |
| In Vivo | CP-346086 (1-100 mg/kg; oral gavage once daily for 2 weeks) reduces plasma total, VLDL, and LDL cholesterol and triglycerides in mice[1]. CP-346086 (25 mg/kg; a single p.o.) results in an almost complete inhibition of Tyloxapol-induced triglyceride accumulation in fasted rats[1]. CP-346086 (0.1-10 mg/kg; a single p.o.) reduces acute plasma triglyceride in mice[1]. Animal Model: B6CBAF1J mice[1] Dosage: 1, 2, 10, 20, 100 mg/kg Administration: Oral gavage once daily for 2 weeks Result: Lowered total, VLDL, and LDL cholesterol and triglycerides dose dependently with 23%, 33%, 75%, and 62% reductions at 10 mg/kg/day. |
| References |
| Molecular Formula | C26H22F3N5O |
|---|---|
| Molecular Weight | 477.48100 |
| Exact Mass | 477.17800 |
| PSA | 73.91000 |
| LogP | 5.31200 |
| Storage condition | 2-8°C |
| 2-[[3-(4-chlorophenyl)-3-[4-(1,3-thiazole-2-carbonyl)phenoxy]propyl]-methylamino]acetic acid |