OR-S0

Modify Date: 2024-01-20 11:02:59

OR-S0 Structure
OR-S0 structure
Common Name OR-S0
CAS Number 1809336-90-0 Molecular Weight 616.763
Density N/A Boiling Point N/A
Molecular Formula C34H44N6O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of OR-S0


OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM).OR-S0 inhibits H3K27me3 in HCT116 cells with IC50 of 24 nM, inhibited the growth of KARPAS‐422 cells in a dose‐dependent manner with GI50 of 210 nM.

 Names

Name OR-S0

 OR-S0 Biological Activity

Description OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM).OR-S0 inhibits H3K27me3 in HCT116 cells with IC50 of 24 nM, inhibited the growth of KARPAS‐422 cells in a dose‐dependent manner with GI50 of 210 nM.
References 1. Daisuke Honma, et al. Cancer Sci. 2017 Oct;108(10):2069-2078.

 Chemical & Physical Properties

Molecular Formula C34H44N6O5
Molecular Weight 616.763