Xeglyze

Modify Date: 2024-01-04 18:14:04

Xeglyze structure	Common Name	Xeglyze
	CAS Number	1762-34-1	Molecular Weight	184.237
	Density	1.1±0.1 g/cm3	Boiling Point	315.7±37.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₂N₂	Melting Point	114-117 °C(lit.)
	MSDS	Chinese USA	Flash Point	119.3±18.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Xeglyze

Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse[1][2].

Name	5-methyl-2-(5-methylpyridin-2-yl)pyridine
Synonym	More Synonyms

Description	Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
In Vitro	Abametapir is capable of chelating heavy metal ions, including iron, copper, and zinc, and is therefore able to interact with a range of targets within the insect that require metal co-factors for function, including metalloproteinases[2].
References	[1]. Vernon Morrison Bowles, et al. Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74%, on Louse Eggs: A Randomized, Double-Blind Study. Glob Pediatr Health. 2019; 6: 2333794X19831295. [2]. Vernon M. Bowles, et al. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2017 Jan; 54(1): 167-172.

Density	1.1±0.1 g/cm3
Boiling Point	315.7±37.0 °C at 760 mmHg
Melting Point	114-117 °C(lit.)
Molecular Formula	C₁₂H₁₂N₂
Molecular Weight	184.237
Flash Point	119.3±18.1 °C
Exact Mass	184.100052
PSA	25.78000
LogP	2.20
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.566

Xeglyze MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW1766000

CHEMICAL NAME :: 2,2'-Bipyridine, 5,5'-dimethyl-

CAS REGISTRY NUMBER :: 1762-34-1

BEILSTEIN REFERENCE NO. :: 0123183

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H12-N2

MOLECULAR WEIGHT :: 184.26

WISWESSER LINE NOTATION :: T6NJ E1 B- BT6NTJ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,815,1985

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DW1766000
HS Code	2933399090

Precursor 10
CAS#:3510-66-5 2-Bromo-5-picoline CAS#:1603-41-4 2-Amino-5-methy... CAS#:189195-41-3 5-Methyl-2-(tri... CAS#:109-04-6 2-Bromopyridine
CAS#:109-09-1 2-Chloropyridine CAS#:5315-25-3 2-Bromo-6-methy... CAS#:18368-64-4 2-Chloro-5-meth... CAS#:108-99-6 3-Mepy
CAS#:4926-28-7 2-Bromo-4-methy... CAS#:1003-68-5 2-Hydroxy-5-picoline
DownStream 8
CAS#:1802-30-8 5,5′-dicarboxy-... CAS#:244303-60-4 4'-methyl-2,2'-... CAS#:591-22-0 3,5-Dimethylpyridine CAS#:1762-46-5 diethyl 2,2'-bi...
CAS#:7647-14-5 sodium chloride CAS#:117585-58-7 2-[5-(bromometh... CAS#:4444-36-4 6-(5-carbamoylp... CAS#:631898-94-7 5-(azidomethyl)...

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synthesis, characterization and crystal structure determination of iron (III) hetero-ligand complexes containing 2, 2'-bipyridine, 5, 5'-dimethyl-2, 2'-bipyridine and chloride, [Fe(bipy)Cl₄][bipy·H] and [Fe(dmbipy)₂Cl₂][FeCl₄]. Amani V, et al.

Polyhedron 26(15) , 4257-4262, (2007)

5,5'-Dimethyl-2,2'-bipyridyl

5,5′-dimethyl-2,2′-bipyridine

5,5'-dimethyl-bpy

5,5'-Dimethyl-2,2'-dipyridyl

5,5'-dimethyl-2,2'-bipy

6,6'-Di-3-picoline

MFCD01740554

5,5'-dimethyl-2,2'-bispyridine

Xeglyze

2,2'-BIPYRIDINE,5,5'-DIMETHYL

6,6'-Di-3-picolyl

5,5'-Dimethyl-2,2'-bipyridine

2,2'-Bipyridine, 5,5'-dimethyl-

abametapir

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Xeglyze
Price: ￥448.0/5g ￥168.0/1g ￥1508.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Xeglyze(Abametapir)
Price: $250.0/100mg $450.0/250mg $900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5,5'-Dimethyl-2,2'-dipyridine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 5-methyl-2-(5-methylpyridin-2-yl)pyridine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥500/500 mg

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Xeglyze

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