Corynoxine B

Modify Date: 2024-01-02 10:43:30

Corynoxine B structure	Common Name	Corynoxine B
	CAS Number	17391-18-3	Molecular Weight	384.469
	Density	1.2±0.1 g/cm3	Boiling Point	560.8±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₈N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	293.0±30.1 °C

Use of Corynoxine B

Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. IC50 value:Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction [1].in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2].

Name	rhynchophylline
Synonym	More Synonyms

Description	Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. IC50 value:Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction [1].in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Alkaloid Research Areas >> Cancer
References	[1]. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54. [2]. Sakakibara I, et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Natural Products >> Alkaloid

Research Areas >> Cancer

References

[1]. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54.

[2]. Sakakibara I, et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6.

Density	1.2±0.1 g/cm3
Boiling Point	560.8±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₈N₂O₄
Molecular Weight	384.469
Flash Point	293.0±30.1 °C
Exact Mass	384.204895
PSA	67.87000
LogP	3.31
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.596
Storage condition	-20°C

Corynoxeine

CAS#:630-94-4

~96%

Corynoxine B

CAS#:17391-18-3

Literature: Wanner, Martin J.; Ingemann, Steen; Van Maarseveen, Jan H.; Hiemstra, Henk European Journal of Organic Chemistry, 2013 , # 6 p. 1100 - 1106

Precursor 1
CAS#:630-94-4 Corynoxeine
DownStream 0

Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,3R,6'S,7'S,8'aS)-

Corynoxine B

Methyl (7β,16E)-16-(methoxymethylene)-2-oxocorynoxan-17-oate

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Corynoxine B
Price: ￥1768.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Corynoxine B
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Corynoxine B
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $191/10mM*1mLinDMSO

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Corynoxine B

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