12-epi-TadalafilTadalafil
Modify Date: 2024-01-02 22:20:08
12-epi-TadalafilTadalafil structure
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Common Name | 12-epi-TadalafilTadalafil | ||
|---|---|---|---|---|
| CAS Number | 171596-27-3 | Molecular Weight | 389.40 | |
| Density | 1.51±0.1 g/cm3 (20 ºC 760 Torr) | Boiling Point | N/A | |
| Molecular Formula | C22H19N3O4 | Melting Point | 295-296 ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of 12-epi-TadalafilTadalafilcis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1]. |
| Name | (6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione |
|---|---|
| Synonym | More Synonyms |
| Description | cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1]. |
|---|---|
| Related Catalog | |
| Target |
PDE5:0.09 μM (IC50) |
| In Vitro | cis-Tadalafil (Compound 12b) 抑制 PDE5，IC50 为 0.09 μM[1]。 |
| References |
| Density | 1.51±0.1 g/cm3 (20 ºC 760 Torr) |
|---|---|
| Melting Point | 295-296 ºC |
| Molecular Formula | C22H19N3O4 |
| Molecular Weight | 389.40 |
| Exact Mass | 389.13800 |
| PSA | 74.87000 |
| LogP | 2.08710 |
| Water Solubility | Insuluble (8.6E-3 g/L) (25 ºC) |
|
~95%
12-epi-Tadalafi... CAS#:171596-27-3 |
| Literature: Tetrahedron Asymmetry, , vol. 19, # 4 p. 435 - 442 |
|
~81%
12-epi-Tadalafi... CAS#:171596-27-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542 |
|
~1%
12-epi-Tadalafi... CAS#:171596-27-3 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515 |
|
~%
12-epi-Tadalafi... CAS#:171596-27-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542 |
|
~%
12-epi-Tadalafi... CAS#:171596-27-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542 |
|
~%
12-epi-Tadalafi... CAS#:171596-27-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542 |
|
~%
12-epi-Tadalafi... CAS#:171596-27-3 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515 |
|
~%
12-epi-Tadalafi... CAS#:171596-27-3 |
| Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515 |
![(1R,3S)-1-benzo[1,3]dioxol-5-yl-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester structure](https://www.chemsrc.com/caspic/438/629652-44-4.png)
![(1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester structure](https://www.chemsrc.com/caspic/129/171596-44-4.png)
![(1R,2S,3R)-(+)-3-[N-(BENZENESULFONYL)-N-(3,5-DIMETHYL-PHENYL)AMINO]-2-BORNANOL structure](https://www.chemsrc.com/caspic/243/171596-41-1.png)
| UNII-E319TQ0B6R |
| cis-ent-Tadalafil |
| PYR403 |
| 12-epi-TadalafilTadalafil |
| Tadalafil Impurity 13 |