ABT-089

Modify Date: 2024-01-07 15:48:13

ABT-089 structure	Common Name	ABT-089
	CAS Number	161417-03-4	Molecular Weight	192.25800
	Density	1.046g/cm3	Boiling Point	302.7ºC at 760mmHg
	Molecular Formula	C₁₁H₁₆N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	136.9ºC

Use of ABT-089

Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1].

Name	2-Methyl-3-[(2S)-2-pyrrolidinylmethoxy]pyridine

Description	Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	Ki: 16 nM (α4β2* nAChR)[1]
References	[1]. Sullivan JP, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. [2]. Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8.

Density	1.046g/cm3
Boiling Point	302.7ºC at 760mmHg
Molecular Formula	C₁₁H₁₆N₂O
Molecular Weight	192.25800
Flash Point	136.9ºC
Exact Mass	192.12600
PSA	34.15000
LogP	1.84960
Vapour Pressure	0.000975mmHg at 25°C
Index of Refraction	1.517

DC Chemicals Limited
China
Product Name: ABT-089
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-METHYL-3-((2S)-PYRROLIDIN-2-YLMETHOXY)PYRIDINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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