acetaminophen glucuronide structure
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Common Name | acetaminophen glucuronide | ||
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CAS Number | 16110-10-4 | Molecular Weight | 330.30500 | |
Density | 1.61g/cm3 | Boiling Point | 697.4ºC at 760mmHg | |
Molecular Formula | C14H14D3NO8 | Melting Point | N/A | |
MSDS | USA | Flash Point | 375.6ºC | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of acetaminophen glucuronideAcetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005)[1][2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[3][4]. |
Name | acetaminophen O-β-D-glucosiduronic acid |
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Synonym | More Synonyms |
Description | Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005)[1][2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[3][4]. |
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Related Catalog | |
In Vitro | Acetaminophen is metabolized in the liver mainly by glucuronidation and sulfation, thus generating the nontoxic metabolites, Acetaminophen glucuronide (APAP-glu). Acetaminophen glucuronide is a substrate for both canalicular Mrp2 and basolateral Mrp3 in rodents[1]. |
References |
Density | 1.61g/cm3 |
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Boiling Point | 697.4ºC at 760mmHg |
Molecular Formula | C14H14D3NO8 |
Molecular Weight | 330.30500 |
Flash Point | 375.6ºC |
Exact Mass | 330.11400 |
PSA | 145.55000 |
Vapour Pressure | 2.03E-20mmHg at 25°C |
Index of Refraction | 1.671 |
Storage condition | 2-8°C |
~47% acetaminophen g... CAS#:16110-10-4 |
Literature: Hayes, John A.; Eccles, Kevin S.; Lawrence, Simon E.; Moynihan, Humphrey A. Carbohydrate Research, 2012 , vol. 349, p. 108 - 112 |
~% acetaminophen g... CAS#:16110-10-4 |
Literature: Hayes, John A.; Eccles, Kevin S.; Lawrence, Simon E.; Moynihan, Humphrey A. Carbohydrate Research, 2012 , vol. 349, p. 108 - 112 |
~% acetaminophen g... CAS#:16110-10-4 |
Literature: Hayes, John A.; Eccles, Kevin S.; Lawrence, Simon E.; Moynihan, Humphrey A. Carbohydrate Research, 2012 , vol. 349, p. 108 - 112 |
~% acetaminophen g... CAS#:16110-10-4 |
Literature: Smith; Williams Biochemical Journal, 1948 , vol. 42, p. 538,541 Biochemical Journal, 1949 , vol. 44, p. 242,245, 250, 251 |
~% acetaminophen g... CAS#:16110-10-4 |
Literature: Boldt, Petra; Rothschild, Markus A.; Kaeferstein, Herbert Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 12 p. 787 - 794 |
~% acetaminophen g... CAS#:16110-10-4 |
Literature: Wong; Grace Jr.; Wright; Browning; Grossman; Bai; Christ Xenobiotica, 2006 , vol. 36, # 12 p. 1178 - 1190 |
Precursor 8 | |
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DownStream 1 | |
Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.
Clin. Exp. Pharmacol. Physiol. 36(1) , 35-42, (2009) 1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over ... |
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Simultaneous LC-MS/MS quantitation of acetaminophen and its glucuronide and sulfate metabolites in human dried blood spot samples collected by subjects in a pilot clinical study.
Bioanalysis 4(12) , 1429-43, (2012) In support of a pilot clinical trial using acetaminophen as the model compound to assess dried blood spot (DBS) sampling as the method for clinical pharmacokinetic sample collection, a novel sensitive... |
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Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.
Int. J. Clin. Pharmacol. Ther. 45(9) , 496-503, (2007) Paracetamol (PCM) is frequently used in pediatric patients with neoplastic disease. It is metabolized mainly by conjugation, but at therapeutic concentrations, a small fraction of the drug undergoes o... |
Acetaminophen D-glucuronide |
[14C]-Acetaminophen glucuronide |
paracetamol glucuronide |
acetaminophen glucuronide |
acetaminophen O-beta-D-glucosiduronic acid |
4-glucuronosido-acetanilide |