HEPPS

Modify Date: 2024-01-02 12:30:48

HEPPS structure	Common Name	HEPPS
	CAS Number	16052-06-5	Molecular Weight	252.331
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₂₀N₂O₄S	Melting Point	237-239 °C(lit.)
	MSDS	Chinese USA	Flash Point	N/A

Use of HEPPS

HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1].

Name	hepps
Synonym	More Synonyms

Description	HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Kim HY, et al. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat Commun. 2015 Dec 8;6:8997.

Density	1.3±0.1 g/cm3
Melting Point	237-239 °C(lit.)
Molecular Formula	C₉H₂₀N₂O₄S
Molecular Weight	252.331
Exact Mass	252.114380
PSA	89.46000
LogP	-2.46
Index of Refraction	1.537
Storage condition	Store at RT.
Water Solubility	H2O: 1 M at 20 °C, clear, colorless

HEPPS MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM2649130

CHEMICAL NAME :: 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-

CAS REGISTRY NUMBER :: 16052-06-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H20-N2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TM2649130
HS Code	29335995

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations.

J. Pharmacol. Toxicol. Methods 70(2) , 188-94, (2014)

Malaria is a major health concern and affects over 300million people a year. Accordingly, there is an urgent need for new efficacious anti-malarial drugs. A major challenge in developing new anti-mala...

Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation.

J. Biol. Chem. 290 , 21615-28, (2015)

Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner sGCα1 subunit and mature into a nitric oxide...

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques.

Nat. Commun. 6 , 8997, (2015)

Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical sympto...

HEPPS

3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic Acid

EINECS 240-198-8

MFCD00006160

3-[4-(2-Hydroxyethyl)-1-piperazinyl]-1-propanesulfonic acid

3-(4-(2-Hydroxyethyl)piperazin-1-yl)propane-1-sulfonic acid

4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component

1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-

3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid

EPPS

4-Hydroxyerhylpiperazine-1-propanesulfonic acid

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: HEPPS
Price: ￥378.0/100g ￥118.0/25g ￥2268.0/500g ￥388.0/100g
Purity: 99.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: EPPS
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: EPPS
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: EPPS
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: hepps
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥325/100g

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HEPPS

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MSDS

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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