Pancuronium dibromide structure
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Common Name | Pancuronium dibromide | ||
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CAS Number | 15500-66-0 | Molecular Weight | 732.67000 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C35H60Br2N2O4 | Melting Point | 214 - 217ºC | |
MSDS | USA | Flash Point | N/A | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of Pancuronium dibromidePancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.Target: nAChRPancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuronium dibromide is a non-depolarizing agent. Pancuronium is a typical non-depolarizing curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is (unlike suxamethonium) a non-depolarizing agent, which means that it causes no spontaneous depolarizations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration [1-3]. |
Name | pancuronium bromide |
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Synonym | More Synonyms |
Description | Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.Target: nAChRPancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuronium dibromide is a non-depolarizing agent. Pancuronium is a typical non-depolarizing curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is (unlike suxamethonium) a non-depolarizing agent, which means that it causes no spontaneous depolarizations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration [1-3]. |
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Related Catalog | |
References |
Melting Point | 214 - 217ºC |
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Molecular Formula | C35H60Br2N2O4 |
Molecular Weight | 732.67000 |
Exact Mass | 730.29200 |
PSA | 52.60000 |
LogP | 0.03610 |
Storage condition | Desiccate at RT |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | Missing Phrase - N15.00950417 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R22 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | TN4930000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
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EINECS 239-532-5 |
MFCD00079223 |
Pancuronium dibromide |
Pancuronium Bromide |