TCO-PNB ester

Modify Date: 2024-01-09 18:31:23

TCO-PNB ester structure	Common Name	TCO-PNB ester
	CAS Number	1438415-89-4	Molecular Weight	291.30
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₇NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TCO-PNB ester

TCO-PNB ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	TCO-PNB ester

Description	TCO-PNB ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₅H₁₇NO₅
Molecular Weight	291.30