Pitavastatin lactone

Modify Date: 2024-01-10 18:53:14

Pitavastatin lactone Structure
Pitavastatin lactone structure
Common Name Pitavastatin lactone
CAS Number 141750-63-2 Molecular Weight 403.445
Density 1.4±0.1 g/cm3 Boiling Point 616.9±55.0 °C at 760 mmHg
Molecular Formula C25H22FNO3 Melting Point 92-95ºC
MSDS N/A Flash Point 326.9±31.5 °C

 Use of Pitavastatin lactone


Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes[1].

 Names

Name Pitavastatin lactone
Synonym More Synonyms

 Pitavastatin lactone Biological Activity

Description Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes[1].
Related Catalog
References

[1]. Fujino H, et al. Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003 Jan;33(1):27-41.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 616.9±55.0 °C at 760 mmHg
Melting Point 92-95ºC
Molecular Formula C25H22FNO3
Molecular Weight 403.445
Flash Point 326.9±31.5 °C
Exact Mass 403.158386
PSA 59.42000
LogP 3.44
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.721

 Synonyms

2H-Pyran-2-one, 6-[(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-, (4R,6S)-
(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one
Pitavastatinlactone
Pitavastatin Impurity 4
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