MK-8318

Modify Date: 2024-01-31 18:38:41

MK-8318 structure	Common Name	MK-8318
	CAS Number	1416581-40-2	Molecular Weight	534.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₆F₄N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MK-8318

MK-8318 is potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.

Name	MK-8318

Description	MK-8318 is potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	CRTH2/DP2 Receptor:5.0 nM (Ki) β-arrestin:3.5 nM (IC50) cAMP:8.0 nM (IC50) CYP3A4:50 μM (IC50) CYP2C9:50 μM (IC50) CYP2D6:50 μM (IC50)
In Vitro	MK-8318 also inhibits β-arrestin, cAMP, CYP3A4, CYP2C9, and CYP2D6 with IC50s of 3.5±2.1 nM, 8.0±6.8 nM, 50 µM, 50 µM and 50 µM[1].
In Vivo	In a sheep model, MK-8318 blocks late airway response (LAR) and airway hyperresponsiveness (AHR) after i.v. infusion at 1 mpk. MK-8318 shows 76% LAR efficacy and 114% AHR efficacy[1].
References	[1]. Huang X, et al. Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma. ACS Med Chem Lett. 2018 Jun 23;9(7):679-684.

Molecular Formula	C₂₇H₂₆F₄N₂O₅
Molecular Weight	534.50

DC Chemicals Limited
China
Product Name: MK-8318
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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