Asenapine citrate

Modify Date: 2024-01-11 12:59:15

Asenapine citrate Structure
Asenapine citrate structure
Common Name Asenapine citrate
CAS Number 1411867-74-7 Molecular Weight 477.89
Density N/A Boiling Point N/A
Molecular Formula C23H24ClNO8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Asenapine citrate


Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[1][2].

 Names

Name Asenapine citrate

 Asenapine citrate Biological Activity

Description Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[1][2].
Related Catalog
Target

5-HT1A Receptor:8.6 (pKi)

5-HT1B Receptor:8.4 (pKi)

5-HT2A Receptor:10.2 (pKi)

5-HT2B Receptor:9.8 (pKi)

5-HT2C Receptor:10.5 (pKi)

5-HT5 Receptor:8.8 (pKi)

5-HT6 Receptor:9.6 (pKi)

5-HT7 Receptor:9.9 (pKi)

α1-adrenergic receptor:8.9 (pKi)

Alpha-2A adrenergic receptor:8.9 (pKi)

Alpha-2B adrenergic receptor:9.5 (pKi)

Alpha-2C adrenergic receptor:8.9 (pKi)

D1 Receptor:8.9 (pKi)

D2 Receptor:8.9 (pKi)

D3 Receptor:9.4 (pKi)

D4 Receptor:9.0 (pKi)

H1 Receptor:9.0 (pKi)

H2 Receptor:8.2 (pKi)

In Vivo Asenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy[2].
References

[1]. M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73.

[2]. Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl). 2008 Feb;196(3):417-29.

 Chemical & Physical Properties

Molecular Formula C23H24ClNO8
Molecular Weight 477.89