polymyxin B2

Modify Date: 2024-01-02 13:00:17

polymyxin B2 structure	Common Name	polymyxin B2
	CAS Number	1404-26-8	Molecular Weight	1189.450
	Density	1.3±0.1 g/cm3	Boiling Point	1572.3±65.0 °C at 760 mmHg
	Molecular Formula	C₅₅H₉₆N₁₆O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	904.7±34.3 °C

Use of polymyxin B2

Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3].

Name	polymyxin B2
Synonym	More Synonyms

Description	Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Martin EL, et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib Nephrol. 2010;167:119-125. [2]. Manchandani P, et al.Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02391-16. [3]. Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Martin EL, et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib Nephrol. 2010;167:119-125.

[2]. Manchandani P, et al.Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02391-16.

[3]. Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1.

Density	1.3±0.1 g/cm3
Boiling Point	1572.3±65.0 °C at 760 mmHg
Molecular Formula	C₅₅H₉₆N₁₆O₁₃
Molecular Weight	1189.450
Flash Point	904.7±34.3 °C
Exact Mass	1188.734253
PSA	490.66000
LogP	-3.40
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.593

Heptanamide, N-[(1S)-3-amino-1-[[[(1S,2R)-1-[[[(1S)-3-amino-1-[[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-15-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclotricos-21-yl]amino]carbonyl]propyl]amino]carbonyl]-2-hydroxypropyl]amino]carbonyl]propyl]-6-methyl-

polymyxin B2

N-[(2S)-4-Amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-({(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl}amino)-2-butanyl]amino}-3-hydroxy-1-oxo-2-butanyl]amino}-1-oxo-2-butanyl]-6-methylheptanamide

DC Chemicals Limited
China
Product Name: Polymyxin B sulphate
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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