Candesartan

Modify Date: 2024-01-02 10:58:51

Candesartan Structure
Candesartan structure
 Common Name Candesartan
CAS Number 139481-59-7 Molecular Weight 440.454
Density 1.4±0.1 g/cm3 Boiling Point 754.8±70.0 °C at 760 mmHg
Molecular Formula C24H20N6O3 Melting Point 183-185°C
MSDS N/A Flash Point 410.3±35.7 °C

 Use of Candesartan


Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.Target: Angiotensin II Receptorcandesartan is indicated for the treatment of hypertension. Results from the CHARM study in the early 2000s demonstrated the morbidity and mortality reduction benefits of candesartan therapy in congestive heart failure. Thus, while ACE inhibitors are still considered first-line therapy in heart failure, candesartan can be used in combination with an ACE to achieve improved mortality and morbidity vs. an ACE alone and additionally is an alternative in patients intolerant of ACE inhibitor therapy.Candesartan (0.5 mg/kg) decreases blood pressure and inhibits AT1 binding in the subfornical organ (SFO), paraventricular nucleus of the hypothalamus (PVN), nucleus of the solitary tract (NTS) and area postrema (AP) in WKY rats. Candesartan (0.3 mg/kg) pretreatment decreases the infarct area by 31% in adult spontaneously hypertensive rats, reduces the CBF decrease at the peripheral area of ischemia and the cortical volume of severe ischemic lesion.

 Names

Name 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
Synonym More Synonyms

 Candesartan Biological Activity

Description Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.Target: Angiotensin II Receptorcandesartan is indicated for the treatment of hypertension. Results from the CHARM study in the early 2000s demonstrated the morbidity and mortality reduction benefits of candesartan therapy in congestive heart failure. Thus, while ACE inhibitors are still considered first-line therapy in heart failure, candesartan can be used in combination with an ACE to achieve improved mortality and morbidity vs. an ACE alone and additionally is an alternative in patients intolerant of ACE inhibitor therapy.Candesartan (0.5 mg/kg) decreases blood pressure and inhibits AT1 binding in the subfornical organ (SFO), paraventricular nucleus of the hypothalamus (PVN), nucleus of the solitary tract (NTS) and area postrema (AP) in WKY rats. Candesartan (0.3 mg/kg) pretreatment decreases the infarct area by 31% in adult spontaneously hypertensive rats, reduces the CBF decrease at the peripheral area of ischemia and the cortical volume of severe ischemic lesion.
Related Catalog
References

[1]. Pfeffer MA, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003 Sep 6;362(9386):759-66.

[2]. Nishimura Y, et al. Chronic peripheral administration of the angiotensin II AT(1) receptor antagonist candesartan blocks brain AT(1) receptors. Brain Res. 2000 Jul 14;871(1):29-38.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 754.8±70.0 °C at 760 mmHg
Melting Point 183-185°C
Molecular Formula C24H20N6O3
Molecular Weight 440.454
Flash Point 410.3±35.7 °C
Exact Mass 440.159698
PSA 118.81000
LogP 5.01
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.719
Storage condition -20°C Freezer

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-ethoxy-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid
Ratacand
Candesartan
Blopress
Amias
Atacand
2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
2-Ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-benzimidazole-7-carboxylic Acid
2-(ethyloxy)-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
MFCD00864463
2-Ethoxy-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid
Candesartan Cilexetil Impurity 7
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Related Compounds: More...
Candesartan-d5
1189650-58-5
Candesartan D4
1346604-70-3
Trityl candesartan
139481-72-4
Candesartan Impurity
150058-29-0
N-Trityl Candesartan
894806-43-0
candesartan cilexetyl
1026042-12-5
Candesartan cilexetil
145040-37-5
2H-2-Ethyl Candesartan
1246819-02-2
1H-1-Ethyl Candesartan
1246817-38-8
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