1-(2,6-Difluorophenyl)ethanone

Modify Date: 2024-01-02 17:44:03

1-(2,6-Difluorophenyl)ethanone Structure
1-(2,6-Difluorophenyl)ethanone structure
Common Name 1-(2,6-Difluorophenyl)ethanone
CAS Number 13670-99-0 Molecular Weight 156.129
Density 1.2±0.1 g/cm3 Boiling Point 178.6±20.0 °C at 760 mmHg
Molecular Formula C8H6F2O Melting Point N/A
MSDS Chinese USA Flash Point 76.7±0.0 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 1-(2,6-Difluorophenyl)ethan-1-one
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 178.6±20.0 °C at 760 mmHg
Molecular Formula C8H6F2O
Molecular Weight 156.129
Flash Point 76.7±0.0 °C
Exact Mass 156.038666
PSA 17.07000
LogP 0.96
Vapour Pressure 1.0±0.3 mmHg at 25°C
Index of Refraction 1.473

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36/37/39
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

~99%

1-(2,6-Difluorophenyl)ethanone Structure

1-(2,6-Difluoro...

CAS#:13670-99-0

Literature: WO2013/85686 A1, ; Page/Page column 22 ;

~10%

1-(2,6-Difluorophenyl)ethanone Structure

1-(2,6-Difluoro...

CAS#:13670-99-0

Literature: WO2013/85686 A1, ; Page/Page column 23 ;

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1-(2,6-Difluorophenyl)ethanone Structure

1-(2,6-Difluoro...

CAS#:13670-99-0

Literature: US4638067 A1, ;

~91%

1-(2,6-Difluorophenyl)ethanone Structure

1-(2,6-Difluoro...

CAS#:13670-99-0

Literature: Tetrahedron, , vol. 49, # 47 p. 10843 - 10854

~77%

1-(2,6-Difluorophenyl)ethanone Structure

1-(2,6-Difluoro...

CAS#:13670-99-0

Literature: Journal of Heterocyclic Chemistry, , vol. 24, # 6 p. 1509 - 1520

~%

1-(2,6-Difluorophenyl)ethanone Structure

1-(2,6-Difluoro...

CAS#:13670-99-0

Literature: Tetrahedron, , vol. 49, # 47 p. 10843 - 10854

~%

1-(2,6-Difluorophenyl)ethanone Structure

1-(2,6-Difluoro...

CAS#:13670-99-0

Literature: WO2004/24738 A1, ; Page/Page column 15 ;

~%

1-(2,6-Difluorophenyl)ethanone Structure

1-(2,6-Difluoro...

CAS#:13670-99-0

Literature: Journal of Medicinal Chemistry, , vol. 11, # 4 p. 814 - 819

 Articles2

More Articles
Synthesis of 2-aminoquinazolines from ortho-fluoroketones. Hynes JB, et al.

J. Heterocycl. Chem. 32(4) , 1185-87, (1995)

Ruthenium-catalyzed arylation of fluorinated aromatic ketones via< i> ortho</i>-selective carbon-fluorine bond cleavage. Kawamoto K, et al.

Tetrahedron Lett. 52(44) , 5888-5890, (2011)

 Synonyms

2,6-Difluoroacetophenone
2′,6′-Difluoroacetophenone
EINECS 237-151-9
2’,6’-Difluoroacetophenone
2',6'-Difluoroacetophenone
MFCD00000328
1-(2,6-Difluorophenyl)ethanone
2-Acetyl-1,3-difluorobenzene
Ethanone, 1-(2,6-difluorophenyl)-
2‘,6‘-Difluoroacetophenone
1-(2,6-Difluorophenyl)ethan-1-one