Itopride-d6 hydrochloride

Modify Date: 2024-01-12 23:14:43

Itopride-d6 hydrochloride Structure
Itopride-d6 hydrochloride structure
Common Name Itopride-d6 hydrochloride
CAS Number 1346601-02-2 Molecular Weight 400.93
Density N/A Boiling Point N/A
Molecular Formula C20H21D6ClN2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Itopride-d6 hydrochloride


Itopride-d6 (hydrochloride) is deuterium labeled Itopride (hydrochloride). Itopride hydrochloride (HSR803), a gastroprokinetic Benzamide (HY-Z0283) derivative, is an inhibitor of acetylcholinesterase (AChE) and dopamine D2 receptor[1][2].

 Names

Name Itopride-d6 hydrochloride

 Itopride-d6 hydrochloride Biological Activity

Description Itopride-d6 (hydrochloride) is deuterium labeled Itopride (hydrochloride). Itopride hydrochloride (HSR803), a gastroprokinetic Benzamide (HY-Z0283) derivative, is an inhibitor of acetylcholinesterase (AChE) and dopamine D2 receptor[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8.

[3]. Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mosapride, and Itopride on Gastric Emptying in Mice. Biol Pharm Bull. 2008 Oct;31(10):1917-22.

 Chemical & Physical Properties

Molecular Formula C20H21D6ClN2O4
Molecular Weight 400.93