5-A-RU hydrochloride
Modify Date: 2024-01-11 12:17:40
5-A-RU hydrochloride structure
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Common Name | 5-A-RU hydrochloride | ||
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| CAS Number | 134452-11-2 | Molecular Weight | 312.71 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H17ClN4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 5-A-RU hydrochloride5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU hydrochloride forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways[1][2][3]. |
| Name | 5-A-RU hydrochloride |
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| Description | 5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU hydrochloride forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways[1][2][3]. |
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| Related Catalog | |
| In Vitro | The MAIT antigens formed by the reactions between 5-A-RU hydrochloride and glyoxal/methylglyoxal are simple adducts, 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), respectively, which bound to MR1 as shown by crystal structures of MAIT TCR ternary complexes[1]. 5-A-RU hydrochloride presents in diverse bacteria and yeast as well as plants. 5-A-RU plays an important role in MAIT cell activation, MR1 could not be refolded efficiently with 5-ARU alone. 5-A-RU is a precursor for MAIT cell ligand[2]. 5-A-RU hydrochloride can react extemporaneously with glyoxal and methylglyoxal to generate pyrimidine adducts that activate mouse MAIT cells from STg (iVa19) and DTg (iVa19Vb6) animals[3]. |
| In Vivo | 5-A-RU hydrochloride (100 nM; i.p.; 18 hours) and methylglyoxal (MeG) are mixed extemporaneously, MAIT cells are activated in iVa19 Cα-/- Tg mice (generated on the C57BL/6 background)[3]. |
| References |
| Molecular Formula | C9H17ClN4O6 |
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| Molecular Weight | 312.71 |