Span 80

Modify Date: 2024-01-01 21:42:35

Span 80 structure	Common Name	Span 80
	CAS Number	1338-43-8	Molecular Weight	428.603
	Density	1.1±0.1 g/cm3	Boiling Point	579.3±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₄₄O₆	Melting Point	0.986ºC
	MSDS	Chinese USA	Flash Point	186.2±23.6 °C

Use of Span 80

Sorbitan monooleate is a renewable polyol with unique molecular structures for the development and design of bio-based waterborne polyurethane (WPU) with versatility and excellent mechanical properties. Sorbitan monooleate can be used as an excipient, such as nonionic surfactants, emulsifiers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

Name	Span 80
Synonym	More Synonyms

Description	Sorbitan monooleate is a renewable polyol with unique molecular structures for the development and design of bio-based waterborne polyurethane (WPU) with versatility and excellent mechanical properties. Sorbitan monooleate can be used as an excipient, such as nonionic surfactants, emulsifiers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Deng H, et al. UV resistance, anticorrosion and high toughness bio-based waterborne polyurethane enabled by a Sorbitan monooleate[J]. Chemical Engineering Journal, 2022, 446: 137124. [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Deng H, et al. UV resistance, anticorrosion and high toughness bio-based waterborne polyurethane enabled by a Sorbitan monooleate[J]. Chemical Engineering Journal, 2022, 446: 137124.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Density	1.1±0.1 g/cm3
Boiling Point	579.3±50.0 °C at 760 mmHg
Melting Point	0.986ºC
Molecular Formula	C₂₄H₄₄O₆
Molecular Weight	428.603
Flash Point	186.2±23.6 °C
Exact Mass	428.313782
PSA	96.22000
LogP	7.14
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.506
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.

Span 80 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG2932400

CHEMICAL NAME :: Sorbitan, monooleate

CAS REGISTRY NUMBER :: 1338-43-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C24-H44-O6

MOLECULAR WEIGHT :: 428.68

WISWESSER LINE NOTATION :: T5OTJ BV1OV8U9 CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 254 gm/kg/6W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - pigmented or nucleated red blood cells

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 100 ppm

REFERENCE :: BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,630,1971 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83475 No. of Facilities: 11289 (estimated) No. of Industries: 95 No. of Occupations: 73 No. of Employees: 71826 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83475 No. of Facilities: 14163 (estimated) No. of Industries: 127 No. of Occupations: 106 No. of Employees: 200724 (estimated) No. of Female Employees: 58462 (estimated)

Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	T+
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	WG2932400
HS Code	34021300

HS Code	34021300

Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain.

J. Neuroinflammation 11 , 128, (2014)

An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggest...

Maltodextrin fast dissolving films for quercetin nanocrystal delivery. A feasibility study.

Carbohydr. Polym. 121 , 217-23, (2015)

The objective of this study was to evaluate the feasibility to prepare fast dissolving films as quercetin nanocrystal delivery systems, using maltodextrins as film forming material and glycerin as pla...

Anionic nanoparticles based on Span 80 as low-cost, simple and efficient non-viral gene-transfection systems.

Int. J. Pharm. 476(1-2) , 23-30, (2015)

The existing strategies in the design of non-viral vectors for gene therapy are primarily conceived for cationic systems. However, the safety concerns associated with the use of positively charged sys...

Sorbitane monooleate,sorbitan oleate

Sorbitan Monooleate

armotanmo

EINECS 215-665-4

sorgen40

o250

Oleic acid compound with (2R,3R,4S)-2-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol

glycomulo

montan80

(R)-1-((2S,3R,4S)-3,4-Dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl oleate

ml33f

ml55f

mo33f

(Sorbitan Monooleate)

MFCD00080948

ionets80

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Span 80
Price: ￥78.0/500g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sorbitan monooleate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Span80(=SorbitanMonooleate)
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Span 80 suppliers

Span 80 price

Span 80

Use of Span 80

Names

Span 80 Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Customs

Articles56

Synonyms