S-Acetyl-PEG8-OH

Modify Date: 2024-01-08 18:47:57

S-Acetyl-PEG8-OH Structure
S-Acetyl-PEG8-OH structure
Common Name S-Acetyl-PEG8-OH
CAS Number 1334177-81-9 Molecular Weight 428.538
Density 1.1±0.1 g/cm3 Boiling Point 512.3±50.0 °C at 760 mmHg
Molecular Formula C18H36O9S Melting Point N/A
MSDS N/A Flash Point 263.6±30.1 °C

 Use of S-Acetyl-PEG8-OH


S-Acetyl-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name S-acetyl-PEG8 alcohol
Synonym More Synonyms

 S-Acetyl-PEG8-OH Biological Activity

Description S-Acetyl-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 512.3±50.0 °C at 760 mmHg
Molecular Formula C18H36O9S
Molecular Weight 428.538
Flash Point 263.6±30.1 °C
Exact Mass 428.208008
LogP -2.13
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.478

 Synonyms

MFCD13185027
Ethanethioic acid, S-(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl) ester
S-(23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl) ethanethioate
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