G-29701 structure
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Common Name | G-29701 | ||
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CAS Number | 129-20-4 | Molecular Weight | 324.37400 | |
Density | 1.241g/cm3 | Boiling Point | 485.6ºC at 760mmHg | |
Molecular Formula | C19H20N2O3 | Melting Point | 109-111°C | |
MSDS | Chinese USA | Flash Point | 247.5ºC | |
Symbol |
GHS07, GHS09 |
Signal Word | Warning |
Use of G-29701Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2]. |
Name | oxyphenbutazone |
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Synonym | More Synonyms |
Description | Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2]. |
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Related Catalog | |
Target |
COX[1] |
In Vitro | Oxyphenbutazone enhances the anticancer efficiency of methotrexate (MTX) in Hep3B cells[1]. Oxyphenbutazone (2.5 -7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells[1]. Oxyphenbutazone exhibits reparative effects in the hepatocytes[1]. Cell Cytotoxicity Assay[1] Cell Line: Hep3B cells Concentration: 2.5 µM, 5 µM, 7.5 µM Incubation Time: 48 hours Result: Enhanced the cytotoxicity of MTX. |
In Vivo | Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.)[1]. Animal Model: 5–6 weeks Wistar strain albino male rats (150–220 g)[1] Dosage: 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week) Administration: Oral administration; once a week; in two divided doses; for 13 weeks Result: Exerted potential anticancer activity in rats when co-treatment with MTX. |
References |
Density | 1.241g/cm3 |
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Boiling Point | 485.6ºC at 760mmHg |
Melting Point | 109-111°C |
Molecular Formula | C19H20N2O3 |
Molecular Weight | 324.37400 |
Flash Point | 247.5ºC |
Exact Mass | 324.14700 |
PSA | 60.85000 |
LogP | 3.62340 |
Vapour Pressure | 4.7E-10mmHg at 25°C |
Index of Refraction | 1.61 |
Storage condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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~% G-29701 CAS#:129-20-4 |
Literature: Helvetica Chimica Acta, , vol. 40, p. 395,399 |
~% G-29701 CAS#:129-20-4 |
Literature: Helvetica Chimica Acta, , vol. 40, p. 395,399 |
~% G-29701 CAS#:129-20-4 |
Literature: Helvetica Chimica Acta, , vol. 40, p. 395,399 |
~% G-29701 CAS#:129-20-4 |
Literature: Helvetica Chimica Acta, , vol. 40, p. 395,399 |
~% G-29701 CAS#:129-20-4 |
Literature: Helvetica Chimica Acta, , vol. 40, p. 395,399 |
~% G-29701 CAS#:129-20-4 |
Literature: Helvetica Chimica Acta, , vol. 40, p. 395,399 |
~% G-29701 CAS#:129-20-4 |
Literature: Helvetica Chimica Acta, , vol. 40, p. 395,399 |
~% G-29701 CAS#:129-20-4 |
Literature: Experientia, , vol. 15, p. 95 |
~% G-29701 CAS#:129-20-4
Detail
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Literature: Journal of Pharmaceutical Sciences, , vol. 70, # 4 p. 460 - 461 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part I.
Adverse Drug React. Acute Poisoning Rev. 5(2) , 97-136, (1986)
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Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part II.
Adverse Drug React. Acute Poisoning Rev. 5(3) , 181-96, (1986)
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Disposition and tolerance of suxibuzone in horses.
Equine Vet. J. 31(5) , 411-6, (1999) Suxibuzone (SBZ), a nonsteroidal anti-inflammatory drug, was administered to 6 horses at a dose rate of 7.5 mg/kg bwt by intravenous (i.v.) route. Plasma and synovial fluid concentrations of suxibuzon... |
p-Oxyphenylbutazone |
oxyphenbutazon |
4-butyl-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione |
4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione G 27202 |
Oxazolidin |
ossifenbutazone |
EINECS 204-936-2 |
oxyphenylbutazone |
MFCD00057278 |
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Oxyphenbutazone |
Tanderil |
Oxiphenbutazone |
Oxi-Fenibutol |
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