β3-AR agonist 1

Modify Date: 2024-01-09 13:13:52

β3-AR agonist 1 structure	Common Name	β3-AR agonist 1
	CAS Number	1283125-73-4	Molecular Weight	444.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₈N₄O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of β3-AR agonist 1

β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1].

Name	β3-AR agonist 1

Description	β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	EC50: 18 nM (β3-AR)[1]
In Vivo	β3-AR agonist 1 (compound 15) shows dose-dependent β3-AR-mediated responses in marmoset urinary bladder smooth muscle, has a desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats[1].
References	[1]. Wada Y, et al. Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects. J Med Chem. 2017 Apr 27;60(8):3252-3265.

Molecular Formula	C₂₂H₂₈N₄O₄S
Molecular Weight	444.55