Escitalopram

Modify Date: 2024-01-02 21:42:45

Escitalopram Structure
Escitalopram structure
 Common Name Escitalopram
CAS Number 128196-01-0 Molecular Weight 324.39
Density 1.2±0.1 g/cm3 Boiling Point 428.3±45.0 °C at 760 mmHg
Molecular Formula C20H21FN2O Melting Point N/A
MSDS N/A Flash Point 212.8±28.7 °C

 Use of Escitalopram


Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.Target: SSRIsEscitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.

 Names

Name escitalopram
Synonym More Synonyms

 Escitalopram Biological Activity

Description Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.Target: SSRIsEscitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.
Related Catalog
Target

Human Endogenous Metabolite
References

[1]. Zhang, P., et al., Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbon itrile) analogues at monoamine transporters. J Med Chem, 2010. 53(16): p. 6112-21.

[2]. Pastoor, D. and J. Gobburu, Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol, 2014. 10(1): p. 121-8.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 428.3±45.0 °C at 760 mmHg
Molecular Formula C20H21FN2O
Molecular Weight 324.39
Flash Point 212.8±28.7 °C
PSA 110.86000
LogP 2.51
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.591
Storage condition 2-8℃

 Safety Information

HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

MFCD06407826
UNII-4O4S742ANY
Escitalopram
5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, (1S)-
(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile
Seroplex
Citalopram
(+)-Citalopram
Lexapro
(S)-citalopram
S(+)-citalopram
Cipralex
S-(+)-Citalopram
(1S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
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Related Compounds: More...
Escitalopram oxalate
219861-08-2
Escitalopram Impurity
91283-87-3
Escitalopram-d6 oxalate
1217733-09-9
N-desmethyl-escitalopram
33458-36-5
Escitalopram E Oxalate Impurity
1217846-85-9
Chemsrc provides Escitalopram(CAS#:128196-01-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Escitalopram are included as well.>> amp version: Escitalopram

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