MK-7622

Modify Date: 2024-01-06 22:54:36

MK-7622 structure	Common Name	MK-7622
	CAS Number	1227923-29-6	Molecular Weight	399.485
	Density	1.3±0.1 g/cm3	Boiling Point	643.0±65.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₂₅N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	342.7±34.3 °C

Use of MK-7622

MK-7622 is a muscarinic M1 receptor positive allosteric modulator.Target: M1 receptorMK-7622 is useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders.

Name	3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]b enzo[h]quinazolin-4(3H)-one
Synonym	More Synonyms

Description	MK-7622 is a muscarinic M1 receptor positive allosteric modulator.Target: M1 receptorMK-7622 is useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease
References	[1]. Kuduk Scott D, et al. Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators. From PCT Int. Appl. (2012), WO 2012047702 A1 20120412. [2]. Kuduk Scott D, et al. Benzoquinazolinone derivatives as M1 receptor positive allosteric modulators and their preparation, pharmaceutical compositions and use in the treatment of diseases. From PCT Int. Appl. (2010), WO 2010059773 A1 20100527.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Neurological Disease

References

[1]. Kuduk Scott D, et al. Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators. From PCT Int. Appl. (2012), WO 2012047702 A1 20120412.

[2]. Kuduk Scott D, et al. Benzoquinazolinone derivatives as M1 receptor positive allosteric modulators and their preparation, pharmaceutical compositions and use in the treatment of diseases. From PCT Int. Appl. (2010), WO 2010059773 A1 20100527.

Density	1.3±0.1 g/cm3
Boiling Point	643.0±65.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₅N₃O₂
Molecular Weight	399.485
Flash Point	342.7±34.3 °C
Exact Mass	399.194672
PSA	68.01000
LogP	3.37
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.687

6-(6-chloropyri...

CAS#:1227923-94-5

methylzinc chloride

CAS#:5158-46-3

MK-7622

CAS#:1227923-29-6

Literature: WO2012/47702 A1, ; Page/Page column 39 ; WO 2012/047702 A1

Precursor 2
CAS#:1227923-94-5 6-(6-chloropyri... CAS#:5158-46-3 methylzinc chloride
DownStream 0

3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]quinazolin-4(3H)-one

(S)-3-(1-AMINOETHYL)BENZENAMINE

3-[(1S)-1-azanylethyl]aniline

Benzo[h]quinazolin-4(3H)-one, 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]-

(S)-1-(3-Aminophenyl)-1-aminoethane

3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one

MK-7622

DC Chemicals Limited
China
Product Name: MK7622
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $121/10mM*1mLinDMSO

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MK-7622

Use of MK-7622

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MK-7622 Biological Activity

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Precursor & DownStream

Synonyms