1,3-Diphenylpropane-1,3-dione

Modify Date: 2024-01-02 10:05:39

1,3-Diphenylpropane-1,3-dione structure	Common Name	1,3-Diphenylpropane-1,3-dione
	CAS Number	120-46-7	Molecular Weight	224.255
	Density	1.1±0.1 g/cm3	Boiling Point	357.4±0.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₂O₂	Melting Point	77-79 °C(lit.)
	MSDS	Chinese USA	Flash Point	146.9±20.2 °C

Use of 1,3-Diphenylpropane-1,3-dione

Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].

Name	dibenzoylmethane
Synonym	More Synonyms

Description	Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Metabolic Disease
In Vitro	Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h[1]. Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells.Dibenzoylmethane does not show significant cytotoxicity[1].
In Vivo	Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice[1]. Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice[1].
References	[1]. Mingnan Cao, et al. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017 Nov;19(6):1703-1714.

Density	1.1±0.1 g/cm3
Boiling Point	357.4±0.0 °C at 760 mmHg
Melting Point	77-79 °C(lit.)
Molecular Formula	C₁₅H₁₂O₂
Molecular Weight	224.255
Flash Point	146.9±20.2 °C
Exact Mass	224.083725
PSA	34.14000
LogP	3.04
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.584
Storage condition	Store at RT.
Stability	Stable. Incompatible with strong oxidizing agents.

1,3-Diphenylpropane-1,3-dione MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ1930000

CHEMICAL NAME :: 1,3-Propanedione, 1,3-diphenyl-

CAS REGISTRY NUMBER :: 120-46-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H12-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,28,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4833 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TZ1930000
HS Code	2914399090

Precursor 10
CAS#:98-88-4 Benzoyl chloride CAS#:98-86-2 Acetophenone CAS#:93-58-3 Methyl benzoate CAS#:100-52-7 Benzaldehyde
CAS#:70-11-1 2-Bromoacetophenone CAS#:532-27-4 2-Chloroacetophenone CAS#:7338-94-5 2-Propyn-1-one,... CAS#:93-89-0 Ethyl benzoate
CAS#:5411-12-1 1,3-diphenyl-2,... CAS#:611-91-6 1-Propanone, 2,...
DownStream 8
CAS#:109801-24-3 2-fluoro-1,3-di... CAS#:365-00-4 2,2-DIFLUORO-1,... CAS#:3389-54-6 N-BENZOYL PYRRO... CAS#:109028-59-3 5,7-diphenyl-2,...
CAS#:1603-79-8 Ethyl oxophenyl... CAS#:93-89-0 Ethyl benzoate CAS#:55-21-0 Benzamide CAS#:85078-58-6 (5-phenyl-1,3,4...

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

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1,3-Diphenyl-1,3-propanedione

1,3-diphenylpropane-1,3-dione

Dibenzoylmethane

MFCD00003085

phenacyl phenyl ketone

EINECS 204-398-9

1,3-Propanedione, 1,3-diphenyl-

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1,3-Diphenylpropane-1,3-dione
Price: ￥348.0/500g ￥118.0/100g
Purity: 99.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Dibenzoylmethane
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dibenzoylmethane
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM CAS:120-46-7 Dibenzoylmethane
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

HENAN NEWBLUE CHEMICAL CO.,LTD
China
Product Name: DBM / Dibenzoyl methane
Price: ￥Inquiry/1ton ￥Inquiry/20ton ￥Inquiry/100ton ￥Inquiry/500ton
Purity: 99.0%
Stocking Period: 1 Day
Contact: Anson

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