INT-777 R-enantiomer

Modify Date: 2024-01-14 23:04:06

INT-777 R-enantiomer structure	Common Name	INT-777 R-enantiomer
	CAS Number	1198786-98-9	Molecular Weight	450.651
	Density	1.1±0.1 g/cm3	Boiling Point	602.8±55.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	332.4±28.0 °C

Use of INT-777 R-enantiomer

INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.

Name	INT-777 R-enantiomer
Synonym	More Synonyms

Description	INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPCR19 Research Areas >> Others
In Vivo	INT-777 (R-enantiomer) is more choleretic than CA (4), but less than INT-777[1].
References	[1]. Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.

Density	1.1±0.1 g/cm3
Boiling Point	602.8±55.0 °C at 760 mmHg
Molecular Formula	C₂₇H₄₆O₅
Molecular Weight	450.651
Flash Point	332.4±28.0 °C
Exact Mass	450.334534
LogP	3.99
Vapour Pressure	0.0±3.9 mmHg at 25°C
Index of Refraction	1.539
Storage condition	2-8℃

(2R,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-Ethyl-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid

INT-777 (R-enantiomer)

INT-777 R-enantiomer

Use of INT-777 R-enantiomer

Names

INT-777 R-enantiomer Biological Activity

Chemical & Physical Properties

Synonyms