Z-LVG-CHN2
Modify Date: 2024-01-06 10:49:04
Z-LVG-CHN2 structure
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Common Name | Z-LVG-CHN2 | ||
|---|---|---|---|---|
| CAS Number | 119670-30-3 | Molecular Weight | 445.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H31N5O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Z-LVG-CHN2Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease[3]. |
| Name | Z-LEU-VAL-GLY-DIAZOMETHYLKETONE |
|---|---|
| Synonym | More Synonyms |
| Description | Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease[3]. |
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| Related Catalog | |
| Target |
EC50: 190 nM (SAR-COV-2)[3] |
| In Vitro | Z-LVG-CHN2 (0-10 μM; pre-treated for 16 h) inhibits antiviral activities in a discernable dose-dependent manner in Vero E6 cells by designed to capture multicycle replication, exhibiting an EC50 value of 0.19 μM[1]/ Cell Viability Assay[3] Cell Line: Vero E6 cells Concentration: 0.001 μM, 0.003 μM, 0.1 μM, 0.3 μM, 1 μM, 2.5 μM Incubation Time: Pre-treated for 16 h and then cultured for 24 hours Result: Inhibited SARS-COV-2 virus replication in a dose-dependent manner. |
| References |
| Molecular Formula | C22H31N5O5 |
|---|---|
| Molecular Weight | 445.51 |
| Storage condition | −20°C |
| Hazard Codes | Xi |
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| WGK Germany | 3 |
| Z-LEU-VAL-GLY-DIAZOMETHYLKETONE |