Brexpiprazole S-oxide

Modify Date: 2024-01-02 12:46:44

Brexpiprazole S-oxide structure	Common Name	Brexpiprazole S-oxide
	CAS Number	1191900-51-2	Molecular Weight	449.565
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₇N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Brexpiprazole S-oxide

Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

Name	DM-3411
Synonym	More Synonyms

Description	Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	Ki: 0.12 nM (5-HT1A), 0.3 nM (D2L), 0.47 nM (5-HT2A)[2]
References	[1]. Chen B, et al. Effects of 26 Recombinant CYP3A4 Variants on Brexpiprazole Metabolism. Chem Res Toxicol. 2019 Oct 17. [2]. Ishima T, et al. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. Eur Neuropsychopharmacol. 2015 Apr;25(4):505-11. [3]. Yoshimi N, et al. Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator. Eur Neuropsychopharmacol. 2015 Mar;25(3):356-64.

Density	1.4±0.1 g/cm3
Molecular Formula	C₂₅H₂₇N₃O₃S
Molecular Weight	449.565
Exact Mass	449.177307
Index of Refraction	1.693

Benzo[b]thiophenium, 4-[4-[4-[(1,2-dihydro-2-oxo-7-quinolinyl)oxy]butyl]-1-piperazinyl]-1-hydroxy-, inner salt

N22UPQ09R0

4-(4-{4-[(2-Oxo-1,2-dihydro-7-quinolinyl)oxy]butyl}-1-piperazinyl)-1-benzothiophenium-1-olate

DM-3411

UNII:N22UPQ09R0

Brexpiprazole Sulfoxide

Brexpiprazole S-Oxide

Brexpiprazole Impurity 20

DC Chemicals Limited
China
Product Name: Brexpiprazole S-oxide
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

Brexpiprazole S-oxide suppliers

Brexpiprazole S-oxide price

Brexpiprazole S-oxide

Use of Brexpiprazole S-oxide

Names

Brexpiprazole S-oxide Biological Activity

Chemical & Physical Properties

Synonyms