Prasugrel-d4

Modify Date: 2024-04-05 17:41:29

Prasugrel-d4 structure	Common Name	Prasugrel-d4
	CAS Number	1189919-49-0	Molecular Weight	377.46600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₆D₄FNO₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Prasugrel-d4

Prasugrel-d4 is the deuterium labeled Prasugrel[1]. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[2].

Name	[5-[1-(2-fluorophenyl)-2-oxo-2-(2,2,3,3-tetradeuteriocyclopropyl)ethyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl] acetate
Synonym	More Synonyms

Description	Prasugrel-d4 is the deuterium labeled Prasugrel[1]. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Wijeyeratne YD, et al. Anti-platelet therapy: ADP receptor antagonists. Br J Clin Pharmacol. 2011 Oct;72(4):647-57. [3]. Sugidachi A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51.

Molecular Formula	C₂₀H₁₆D₄FNO₃S
Molecular Weight	377.46600
Exact Mass	377.14000
PSA	74.85000
LogP	3.82890

Prasugrel-d5

CS 747

Prasugrel-d4

Use of Prasugrel-d4

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Prasugrel-d4 Biological Activity

Chemical & Physical Properties

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