h-8 dihydrochloride
Modify Date: 2024-01-12 11:18:52
h-8 dihydrochloride structure
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Common Name | h-8 dihydrochloride | ||
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| CAS Number | 113276-94-1 | Molecular Weight | 338.25300 | |
| Density | N/A | Boiling Point | 473.9ºC at 760 mmHg | |
| Molecular Formula | C12H17Cl2N3O2S | Melting Point | 221-222℃ (methanol water ) | |
| MSDS | USA | Flash Point | 240.4ºC | |
Use of h-8 dihydrochlorideH-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor[1]. |
| Name | N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride |
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| Synonym | More Synonyms |
| Description | H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor[1]. |
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| Related Catalog | |
| References |
| Boiling Point | 473.9ºC at 760 mmHg |
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| Melting Point | 221-222℃ (methanol water ) |
| Molecular Formula | C12H17Cl2N3O2S |
| Molecular Weight | 338.25300 |
| Flash Point | 240.4ºC |
| Exact Mass | 337.04200 |
| PSA | 79.47000 |
| LogP | 4.19910 |
| Vapour Pressure | 3.79E-09mmHg at 25°C |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: 25 mg/mL, clear, colorless |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2935009090 |
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h-8 dihydrochloride CAS#:113276-94-1 |
| Literature: Journal of Medicinal Chemistry, , vol. 32, # 1 p. 42 - 46 |
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h-8 dihydrochloride CAS#:113276-94-1 |
| Literature: Journal of Medicinal Chemistry, , vol. 32, # 1 p. 42 - 46 |
|
~%
h-8 dihydrochloride CAS#:113276-94-1 |
| Literature: Journal of Medicinal Chemistry, , vol. 32, # 1 p. 42 - 46 |
![2-[(5-Isoquinolinylsulfonyl)amino]ethyl 4-methylbenzenesulfonate structure](https://www.chemsrc.com/caspic/477/129305-12-0.png)
| Precursor 3 | |
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| DownStream 0 | |
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
Biochemistry 23 , 5036-5041, (1984) Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the... |
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In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.
Mol. Cell. Biol. 9 , 2424, (1989) We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interle... |
| H-8 dihydrochloride |
| MFCD00036962 |