Psammaplin A

Modify Date: 2024-01-12 15:21:06

Psammaplin A structure	Common Name	Psammaplin A
	CAS Number	110659-91-1	Molecular Weight	664.38700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₄Br₂N₄O₆S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Psammaplin A

Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].

Name	OT-Key 21539
Synonym	More Synonyms

Description	Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Epigenetics >> DNA Methyltransferase Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.9 nM (DAC1)[1]
References	[1]. Matthias G J Baud, et al. Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A Against Its Epigenetic Targets. J Med Chem. 2012 Feb 23;55(4):1731-50. [2]. Psammaplin A, a Natural Bromotyrosine Derivative From a Sponge, Possesses the

Molecular Formula	C₂₂H₂₄Br₂N₄O₆S₂
Molecular Weight	664.38700
Exact Mass	661.95000
PSA	214.44000
LogP	4.46400

Hazard Codes	Xi

3-(3-Bromo-4-hydroxy-phenyl)-N-[2-(2-{3-(3-bromo-4-hydroxy-phenyl)-2-[(Z)-hydroxyimino]-propionylamino}-ethyldisulfanyl)-ethyl]-2-[(Z)-hydroxyimino]-propionamide

Li0061

bisprasin

psammaplin A

DC Chemicals Limited
China
Product Name: Psammaplin A
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: psammaplin A
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Psammaplin A

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