Fmoc-His(Trt)-OH

Modify Date: 2024-01-02 11:30:37

Fmoc-His(Trt)-OH Structure
Fmoc-His(Trt)-OH structure
Common Name Fmoc-His(Trt)-OH
CAS Number 109425-51-6 Molecular Weight 619.708
Density 1.2±0.1 g/cm3 Boiling Point 811.7±65.0 °C at 760 mmHg
Molecular Formula C40H33N3O4 Melting Point 150-155 °C(lit.)
MSDS Chinese USA Flash Point 444.7±34.3 °C

 Use of Fmoc-His(Trt)-OH


Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1].

 Names

Name N-Fmoc-N'-trityl-L-histidine
Synonym More Synonyms

 Fmoc-His(Trt)-OH Biological Activity

Description Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1].
Related Catalog
References

[1]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 811.7±65.0 °C at 760 mmHg
Melting Point 150-155 °C(lit.)
Molecular Formula C40H33N3O4
Molecular Weight 619.708
Flash Point 444.7±34.3 °C
Exact Mass 619.247131
PSA 93.45000
LogP 8.03
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.657
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
WGK Germany 3

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 Synonyms

MFCD00043332
N-Fmoc-N'-Trityl-L-Histidine
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine
N-alpha-FMOC-N-Trityl-L-histidine
EINECS 439-640-4
Nα-Fmoc-N(im)-trityl-L-histidine
Na-Fmoc-Nim-trityl-L-histidine
Fmoc-His(Trt)-OH
Nα-[(9H-Fluoren-9-ylMethoxy)carbonyl]-tele-(triphenylMethyl)-L-histidine
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine,
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid
L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-
Nα-Fmoc-τ-trityl-L-histidine
Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-τ-(triphenylmethyl)-L-histidine
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