Kushenol K

Modify Date: 2024-01-02 17:03:45

Kushenol K Structure
Kushenol K structure
Common Name Kushenol K
CAS Number 101236-49-1 Molecular Weight 472.527
Density 1.3±0.1 g/cm3 Boiling Point 722.4±60.0 °C at 760 mmHg
Molecular Formula C26H32O8 Melting Point N/A
MSDS N/A Flash Point 242.4±26.4 °C

 Use of Kushenol K


Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].

 Names

Name Kushenol K
Synonym More Synonyms

 Kushenol K Biological Activity

Description Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].
Related Catalog
Target

HSV-2:147 μM (EC50)

CYP3A4:1.35 μM (Ki)

SGLT

In Vitro When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1]. At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3].
References

[1]. Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.

[2]. E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4.

[3]. Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 722.4±60.0 °C at 760 mmHg
Molecular Formula C26H32O8
Molecular Weight 472.527
Flash Point 242.4±26.4 °C
Exact Mass 472.209717
LogP 3.81
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.614

 Synonyms

4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)-
(2R,3S)-2-(2,4-Dihydroxyphenyl)-3,7-dihydroxy-8-[(2R)-5-hydroxy-2-isopropenyl-5-methylhexyl]-5-methoxy-2,3-dihydro-4H-chromen-4-one
(2R,3S)-2-(2,4-dihydroxyphenyl)-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(prop-1-en-2-yl)hexyl]-5-methoxy-2,3-dihydro-4H-chromen-4-one
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