Kushenol K structure
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Common Name | Kushenol K | ||
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CAS Number | 101236-49-1 | Molecular Weight | 472.527 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 722.4±60.0 °C at 760 mmHg | |
Molecular Formula | C26H32O8 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 242.4±26.4 °C |
Use of Kushenol KKushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3]. |
Name | Kushenol K |
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Synonym | More Synonyms |
Description | Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3]. |
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Related Catalog | |
Target |
HSV-2:147 μM (EC50) CYP3A4:1.35 μM (Ki) SGLT |
In Vitro | When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1]. At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 722.4±60.0 °C at 760 mmHg |
Molecular Formula | C26H32O8 |
Molecular Weight | 472.527 |
Flash Point | 242.4±26.4 °C |
Exact Mass | 472.209717 |
LogP | 3.81 |
Vapour Pressure | 0.0±2.5 mmHg at 25°C |
Index of Refraction | 1.614 |
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)- |
(2R,3S)-2-(2,4-Dihydroxyphenyl)-3,7-dihydroxy-8-[(2R)-5-hydroxy-2-isopropenyl-5-methylhexyl]-5-methoxy-2,3-dihydro-4H-chromen-4-one |
(2R,3S)-2-(2,4-dihydroxyphenyl)-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(prop-1-en-2-yl)hexyl]-5-methoxy-2,3-dihydro-4H-chromen-4-one |