Teriflunomide impurity 3

Modify Date: 2024-01-14 13:29:24

Teriflunomide impurity 3 structure	Common Name	Teriflunomide impurity 3
	CAS Number	1011244-72-6	Molecular Weight	280.245
	Density	1.4±0.1 g/cm3	Boiling Point	327.6±42.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₁F₃N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	151.9±27.9 °C

Use of Teriflunomide impurity 3

Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 µM)[1].

Name	4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide
Synonym	More Synonyms

Description	Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 µM)[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:30 μM (IC50)
In Vitro	Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide; compound 11q) is an amide-bond-reversed compound bearing trifluoromethyl and amino substituents showed potent COX-1-selective inhibitory activity[1].
References	[1]. Hiroki Kakuta, et al. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem. 2008 Apr 24;51(8):2400-11.

Density	1.4±0.1 g/cm3
Boiling Point	327.6±42.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₁F₃N₂O
Molecular Weight	280.245
Flash Point	151.9±27.9 °C
Exact Mass	280.082336
LogP	2.87
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.602
Storage condition	-20°C

Benzamide, 4-amino-N-[4-(trifluoromethyl)phenyl]-

4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide

DC Chemicals Limited
China
Product Name: Teriflunomide impurity 3
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-amino-N-[4-(trifluoromethyl)phenyl]benzamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥550/10 mM * 1 mL in DMSO

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Teriflunomide impurity 3

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