4,4'-methylene-bis-(2-chloroaniline)

Modify Date: 2024-01-07 13:39:00

4,4'-methylene-bis-(2-chloroaniline) Structure
4,4'-methylene-bis-(2-chloroaniline) structure
 Common Name 4,4'-methylene-bis-(2-chloroaniline)
CAS Number 101-14-4 Molecular Weight 267.154
Density 1.44 Boiling Point 412.0±40.0 °C at 760 mmHg
Molecular Formula C13H12Cl2N2 Melting Point 102-107 °C(lit.)
MSDS Chinese USA Flash Point 203.0±27.3 °C
Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09		 Signal Word Danger

 Names

Name 4,4'-methylene-bis-(2-chloroaniline)
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.44
Boiling Point 412.0±40.0 °C at 760 mmHg
Melting Point 102-107 °C(lit.)
Molecular Formula C13H12Cl2N2
Molecular Weight 267.154
Flash Point 203.0±27.3 °C
Exact Mass 266.037750
PSA 52.04000
LogP 3.59
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.671
Stability Stable, but decomposes exothermically, and possibly explosively, above 200 C. Incompatible with strong oxidizing agents.
Water Solubility <0.1 g/100 mL at 25 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY1050000
CHEMICAL NAME :
Benzenamine, 4,4'-methylenebis(2-chloro-
CAS REGISTRY NUMBER :
101-14-4
BEILSTEIN REFERENCE NO. :
1882318
LAST UPDATED :
199712
DATA ITEMS CITED :
74
MOLECULAR FORMULA :
C13-H12-Cl2-N2
MOLECULAR WEIGHT :
267.17
WISWESSER LINE NOTATION :
ZR CG D1R DZ CG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1140 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Kidney, Ureter, Bladder - urine volume increased
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
640 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4050 mg/kg/77W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 gm/kg/89W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
27 gm/kg/79W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
27 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8100 mg/kg/77W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16 gm/kg/77W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
27 gm/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
34 gm/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
21 gm/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24 gm/kg/57W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Micronucleus test

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - rabbit Liver
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3120,1983 *** REVIEWS *** ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.11 mg/m3 (0.01 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,65,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,271,1993 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,246,1987 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,271,1993 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,271,1993 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 39,496,1978 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.02 ppm (0.22 mg/m3);Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.02 ppm (0.22 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.02 ppm (0.2 mg/m3);STEL 0.06 ppm;Skin JAN 1993 OEL-FINLAND:TWA 0.02 ppm (0.2 mg/m3);STEL 0.06 ppm;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.02 ppm (0.22 mg/m3);Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.02 ppm;Skin JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.02 ppm (0.2 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 0.02 ppm (0.22 mg/m3);Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.005 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MOCA-air:10H CA TWA 0.003 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83341 No. of Facilities: 376 (estimated) No. of Industries: 15 No. of Occupations: 13 No. of Employees: 2094 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83341 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 114 (estimated)

 Safety Information

Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Danger
Hazard Statements H302-H341-H350-H410
Precautionary Statements P201-P273-P281-P308 + P313-P501
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T;N
Risk Phrases R22;R45;R50-53
Safety Phrases S53-S45-S60-S61
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS CY1050000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2921590031

 Synthetic Route

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N-benzotriazol-1-ylmethyl-2-chloro-aniline structure

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~44%

4,4'-methylene-bis-(2-chloroaniline) Structure

4,4'-methylene-...

CAS#:101-14-4

N/A structure

N/A

CAS#:129075-90-7
Literature: Synthesis, , p. 341 - 346
N,N'-bis(2-chlorophenyl)methanediamine structure

N,N'-bis(2-chlo...

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2-Chloroaniline structure

2-Chloroaniline

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~%

4,4'-methylene-bis-(2-chloroaniline) Structure

4,4'-methylene-...

CAS#:101-14-4
Literature: Chemische Berichte, , vol. 47, p. 1161
2-Chloroaniline structure

2-Chloroaniline

CAS#:95-51-2

~%

4,4'-methylene-bis-(2-chloroaniline) Structure

4,4'-methylene-...

CAS#:101-14-4
Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2>79, p. 493
Ethanol structure

Ethanol

CAS#:64-17-5
N,N'-bis(2-chlorophenyl)methanediamine structure

N,N'-bis(2-chlo...

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2-Chloroaniline structure

2-Chloroaniline

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~%

4,4'-methylene-bis-(2-chloroaniline) Structure

4,4'-methylene-...

CAS#:101-14-4
Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2>79, p. 493

 Customs

HS Code 2921590031
Summary 2921590031 4,4'-methylenebis(2-chloroaniline)。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

 Articles26

More Articles
[Resolution of overlapping mass spectra of azobiphenyl dyes by subwindow factor analysis technique].

Se Pu 19(2) , 184-7, (2001)

Subwindow factor analysis(SWFA) has been proven to be an effective data processing technique. In this paper, it is applied to the resolution of overlapping GC-MS peaks. A two-component sample of azobi...
New approaches to extraction techniques in determination of 4,4'-methylenebis(2-chloroaniline) in air and water solutions.

Talanta 93 , 117-21, (2012)

Extraction techniques for 4,4'-methylenebis(2-chloroaniline) (MOCA) in air samples and water solutions were developed and compared. Classic techniques for air sampling of MOCA were enhanced by incorpo...
Oxidative DNA damage estimated by plasma 8-hydroxydeoxyguanosine (8-OHdG): influence of 4, 4'-methylenebis (2-chloroaniline) exposure and smoking.

J. Occup. Health 49(5) , 389-98, (2007)

Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By...

 Synonyms

bisamine
Di-(4-amino-3-chlorophenyl)methane
curalinm
4,4'-Methylene bis(2-chloroaniline)
Aniline, 4,4'-methylenebis[2-chloro-
MOCA
MBOCA
4,4'-Methylene bis(o-chloroaniline)
Cyanaset
MFCD00047829
MOCA-A
4,4'-diamino-3,3'-dichlorodiphenylmethane
LD 813
4,4'-Bis(2-chloroanilino)methane
EINECS 202-918-9
4,4'-Methylenebis[2-chlorobenzenamine]
3,3-Dichloro-4,4-Diaminodiphenyl Methane
4,4'-Methylene-bis-2-chloroaniline (MOCA)
4,4'-Methylene-bis(2-chloroaniline)
4,4'-Methylenebis(2-chloroaniline)
3,3'-Dichloro-4,4'-diaminodiphenylmethane
Benzenamine, 4,4'-methylenebis[2-chloro-
DACPM
CL-MDA
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Chemsrc provides 4,4'-methylene-bis-(2-chloroaniline)(CAS#:101-14-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 4,4'-methylene-bis-(2-chloroaniline) are included as well.>> amp version: 4,4'-methylene-bis-(2-chloroaniline)

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