GSK 1562590 hydrochloride

Modify Date: 2022-11-21 16:56:19

GSK 1562590 hydrochloride Structure
GSK 1562590 hydrochloride structure
Common Name GSK 1562590 hydrochloride
CAS Number 1003878-07-6 Molecular Weight 617.95
Density N/A Boiling Point N/A
Molecular Formula C30H31Cl3N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GSK 1562590 hydrochloride


GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT[1].

 Names

Name 4'-[(1R)-1-{[(6,7-Dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino}-2-(1-pyrrolidinyl)ethyl]-3-biphenylcarboxamide hydrochloride (1:1)
Synonym More Synonyms

 GSK 1562590 hydrochloride Biological Activity

Description GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT[1].
Related Catalog
References

[1]. Behm DJ, et, al. GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo. Br J Pharmacol. 2010 Sep;161(1):207-28.  

 Chemical & Physical Properties

Molecular Formula C30H31Cl3N4O4
Molecular Weight 617.95
Exact Mass 616.141113

 Synonyms

4H-1,4-Benzoxazine-4-acetamide, N-[(1R)-1-[3'-(aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-, hydrochloride (1:1)
4'-[(1R)-1-{[(6,7-Dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino}-2-(1-pyrrolidinyl)ethyl]-3-biphenylcarboxamide hydrochloride (1:1)