Tegobuvir

Modify Date: 2024-01-11 21:32:27

Tegobuvir structure	Common Name	Tegobuvir
	CAS Number	1000787-75-6	Molecular Weight	517.401
	Density	1.5±0.1 g/cm3	Boiling Point	558.0±60.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₁₄F₇N₅	Melting Point	N/A
	MSDS	N/A	Flash Point	291.3±32.9 °C

Use of Tegobuvir

Tegobuvir is a specific, covalent inhibitor of the HCV NS5B polymerase.

Name	5-[[6-[2,4-bis(trifluoromethyl)phenyl]pyridazin-3-yl]methyl]-2-(2-fluorophenyl)imidazo[4,5-c]pyridine
Synonym	More Synonyms

Description	Tegobuvir is a specific, covalent inhibitor of the HCV NS5B polymerase.
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
In Vitro	Tegobuvir rapidly increases the proportion of replicons with the Y448H mutation in a dose-dependent manner. After 3 days of treatment, 1.2%, 6.8%, and > 50% of the replicon population expresses Y448H with the use of Tegobuvir at 1, 10, and 20 times its 50% effective concentration, respectively[1]. Tegobuvir exerts anti-HCV activity utilizing a unique chemical activation and subsequent direct interaction with the NS5B protein. Treatment of HCV subgenomic replicon cells with Tegobuvir results in a modified form of NS5B with a distinctly altered mobility on a SDS-PAGE gel[2]. Tegobuvir is potent in GT1a and 1b with mean EC50s of 19.8 and 1.5 nM respectively. For genotype 3a, 4a, and 6a Con chimeras, tegobuvir EC50s are all greater than 100 nM. The F445C NS5B mutations in GT3a, 4a, and 6a chimeric replicons restore tegobuvir potency to EC50 levels comparable to GT1a[3].
Cell Assay	Replicon-containing cells are trypsinized and seeded in cell culture media without G418 in white 96-well plates for EC50 analysis. Stable replicon carrying cell lines are seeded at a density of 5,000 cells per well. Serial threefold dilutions (10 concentrations) of compounds are performed in DMSO followed by further dilution in cell culture media and subsequent addition to cell plates. Compound-treated cells are incubated 72 hours at 37°C in a 5% CO2 incubator.
References	[1]. Bae AS, et al. Allele-specific real-time PCR system for detection of subpopulations of genotype 1a and 1b hepatitis C NS5B Y448H mutant viruses in clinical samples. J Clin Microbiol. 2011 Sep;49(9):3168-74. [2]. Hebner CM, et al. The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function.PLoS One. 2012;7(6):e39163. [3]. Wong KA, et al. Tegobuvir (GS-9190) potency against HCV chimeric replicons derived from consensus NS5B sequences from genotypes 2b, 3a, 4a, 5a, and 6a. Virology. 2012 Jul 20;429(1):57-62.

Density	1.5±0.1 g/cm3
Boiling Point	558.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₅H₁₄F₇N₅
Molecular Weight	517.401
Flash Point	291.3±32.9 °C
Exact Mass	517.113770
PSA	56.49000
LogP	4.07
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.605
Storage condition	2-8℃

5-({6-[2,4-Bis(trifluoromethyl)phenyl]-3-pyridazinyl}methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine

5H-Imidazo[4,5-c]pyridine, 5-[[6-[2,4-bis(trifluoromethyl)phenyl]-3-pyridazinyl]methyl]-2-(2-fluorophenyl)-

tegobuvir

5-({6-[2,4-bis(trifluoromethyl)phenyl]pyridazin-3-yl}methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine

Tegobuvir [USN:INN]

Tegobuvir (USAN/INN)

DC Chemicals Limited
China
Product Name: Tegobuvir
Price: $900.0/100mg $1750.0/250mg $3600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-((6-(2,4-bis(Trifluoromethyl)phenyl)pyridazin-3-yl)Methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $341/10mM*1mLinDMSO

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Tegobuvir

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